Evidence map›Paper›PMID 35729777›Full record

ArticleJournal of the American Chemical Society2022

In Situ Assembly of Platinum(II)-Metallopeptide Nanostructures Disrupts Energy Homeostasis and Cellular Metabolism.

Zhixuan Zhou, Konrad Maxeiner, Pierpaolo Moscariello, Siyuan Xiang, Yingke Wu, Yong Ren, Colette J Whitfield, Lujuan Xu, Anke Kaltbeitzel, Shen Han and 8 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of the American Chemical Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 48 citations in OpenAlex.

  1. Article
  2. Reversible Nucleolar Complex Coacervation by Short Cationic Peptides.Journal of the American Chemical Society · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Chemical science · 2024
    Article
  12. Article
  13. Article
  14. Chemical Reactions in Living Systems.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Review
  15. Review
  16. Article
  17. Exploring the Potential of Metal-Based Candidate Drugs as Modulators of the Cytoskeleton.Chembiochem : a European journal of chemical biology · 2023
    Review
  18. Article
  19. Chemical science · 2023
    Article
  20. Polymer Chemistry in Living Cells.Accounts of chemical research · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 2 institutions in 1 country.

Zhixuan ZhouMax Planck Institute for Polymer Research, 55128 Mainz, Germany.ORCID 0000-0001-8295-5860
Konrad MaxeinerMax Planck Institute for Polymer Research, 55128 Mainz, Germany.
Pierpaolo MoscarielloMax Planck Institute for Polymer Research, 55128 Mainz, Germany.
Siyuan XiangMax Planck Institute for Polymer Research, 55128 Mainz, Germany.
Yingke WuMax Planck Institute for Polymer Research, 55128 Mainz, Germany.
Yong RenMax Planck Institute for Polymer Research, 55128 Mainz, Germany.
Colette J WhitfieldMax Planck Institute for Polymer Research, 55128 Mainz, Germany.
Lujuan XuMax Planck Institute for Polymer Research, 55128 Mainz, Germany.
Anke KaltbeitzelMax Planck Institute for Polymer Research, 55128 Mainz, Germany.
Shen HanMax Planck Institute for Polymer Research, 55128 Mainz, Germany.
David MückeCentral Facility of Materials Science Electron Microscopy, Universität Ulm, 89081 Ulm, Germany.ORCID 0000-0001-9204-1915
Haoyuan QiCentral Facility of Materials Science Electron Microscopy, Universität Ulm, 89081 Ulm, Germany.ORCID 0000-0002-6684-7074
Manfred WagnerMax Planck Institute for Polymer Research, 55128 Mainz, Germany.
Ute KaiserCentral Facility of Materials Science Electron Microscopy, Universität Ulm, 89081 Ulm, Germany.
Katharina LandfesterMax Planck Institute for Polymer Research, 55128 Mainz, Germany.ORCID 0000-0001-9591-4638
Ingo LieberwirthMax Planck Institute for Polymer Research, 55128 Mainz, Germany.ORCID 0000-0003-1323-524X
David Y W NgMax Planck Institute for Polymer Research, 55128 Mainz, Germany.ORCID 0000-0002-0302-0678
Tanja WeilMax Planck Institute for Polymer Research, 55128 Mainz, Germany.ORCID 0000-0002-5906-7205
Max Planck Institute for Polymer Research · DEUniversität Ulm · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nanostructure-based functions are omnipresent in nature and essential for the diversity of life. Unlike small molecules, which are often inhibitors of enzymes or biomimetics with established methods of elucidation, we show that functions of nanoscale structures in cells are complex and can implicate system-level effects such as the regulation of energy and redox homeostasis. Herein, we design a platinum(II)-containing tripeptide that assembles into intracellular fibrillar nanostructures upon molecular rearrangement in the presence of endogenous H

Indexed as

NanostructuresPlatinumAdenosine TriphosphateEnergy MetabolismHomeostasisHydrogen PeroxideAdenosine TriphosphateHydrogen PeroxidePlatinum

Identifiers

PMID35729777
PMCPMC9284552
OpenAlexW4283272474

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.