Evidence map›Paper›PMID 35729464›Full record

ArticleNeurocritical care2022

Cortical Anoxic Spreading Depolarization During Cardiac Arrest is Associated with Remote Effects on Peripheral Blood Pressure and Postresuscitation Neurological Outcome.

Sangwoo Han, Mayra Isabel Contreras, Afsheen Bazrafkan, Masih Rafi, Shirin M Dara, Ani Orujyan, Anais Panossian, Christian Crouzet, Beth Lopour, Bernard Choi and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurocritical care, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Spreading depolarization: A wave that precedes and drives cerebral ischemic cell death-Target for neuroprotection.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Sangwoo HanDepartment of Neurology, University of California, Irvine, Irvine, CA, USA.
Mayra Isabel ContrerasDepartment of Neurology, University of California, Irvine, Irvine, CA, USA.
Afsheen BazrafkanDepartment of Neurology, University of California, Irvine, Irvine, CA, USA.
Masih RafiDepartment of Neurology, University of California, Irvine, Irvine, CA, USA.
Shirin M DaraDepartment of Neurology, University of California, Irvine, Irvine, CA, USA.
Ani OrujyanDepartment of Neurology, University of California, Irvine, Irvine, CA, USA.
Anais PanossianDepartment of Neurology, University of California, Irvine, Irvine, CA, USA.
Christian CrouzetDepartment of Biomedical Engineering, University of California, Irvine, Irvine, CA, USA.
Beth LopourDepartment of Biomedical Engineering, University of California, Irvine, Irvine, CA, USA.
Bernard ChoiDepartment of Biomedical Engineering, University of California, Irvine, Irvine, CA, USA.
Robert H WilsonBeckman Laser Institute and Medical Clinic, University of California, Irvine, Irvine, CA, USA.
Yama AkbariDepartment of Neurology, University of California, Irvine, Irvine, CA, USA. yakbari@uci.edu.ORCID 0000-0003-0729-5617
University of California, Irvine · US

Funding

University of California Health Participation in the National COVID Cohort Collaborative (N3C)UL1TR001414 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M, VILAIN, ERIC J. · 2015 to 2023
$35.1M
Virtual Photonocs TechnologiesP41EB015890 · NIBIB · UNIVERSITY OF CALIFORNIA-IRVINE · PI CHEN, ZHONGPING · 2012 to 2017
$7.0M
Institutional Career Development CoreKL2TR001416 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI CAIOZZO, VINCENT JAMES, DEMETRIOU, MICHAEL · 2015 to 2023
$5.6M
NRSA Training CoreTL1TR001415 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI CAIOZZO, VINCENT JAMES, HEAD, ELIZABETH · 2015 to 2023
$4.2M
Multimodal Optical Imaging of Hyperdynamic Cerebral Responses to Cardiac Arrest and ResuscitationR21EB024793 · NIBIB · UNIVERSITY OF CALIFORNIA-IRVINE · PI AKBARI, YAMA · 2017 to 2019
$925k
NCATS NIH HHS KL2 TR001416NCATS NIH HHS TL1 TR001415NCATS NIH HHS UL1 TR001414NIBIB NIH HHS P41 EB015890NIBIB NIH HHS R21 EB024793
6 · The paper itself

Abstract

backgroundSpreading depolarizations (SDs) are self-propagating waves of neuronal and glial depolarizations often seen in neurological conditions in both humans and animal models. Because SD is thought to worsen neurological injury, the role of SD in a variety of cerebral insults has garnered significant investigation. Anoxic SD is a type of SD that occurs because of anoxia or asphyxia. Although asphyxia leading to a severe drop in blood pressure may affect cerebral hemodynamics and is widely known to cause anoxic SD, the effect of anoxic SD on peripheral blood pressure in the extremities has not been investigated. This relationship is especially important to understand for conditions such as circulatory shock and cardiac arrest that directly affect both peripheral and cerebral perfusion in addition to producing anoxic SD in the brain.

methodsIn this study, we used a rat model of asphyxial cardiac arrest to investigate the role of anoxic SD on cerebral hemodynamics and metabolism, peripheral blood pressure, and the relationship between these variables in 8- to 12-week-old male rats. We incorporated a multimodal monitoring platform measuring cortical direct current simultaneously with optical imaging.

resultsWe found that during anoxic SD, there is decoupling of peripheral blood pressure from cerebral blood flow and metabolism. We also observed that anoxic SD may modify cerebrovascular resistance. Furthermore, shorter time difference between anoxic SDs measured at different locations in the same rat was associated with better neurological outcome on the basis of the recovery of electrocorticography activity (bursting) immediately post resuscitation and the neurological deficit scale score 24 h post resuscitation.

conclusionsTo our knowledge, this is the first study to quantify the relationship between peripheral blood pressure, cerebral hemodynamics and metabolism, and neurological outcome in anoxic SD. These results indicate that the characteristics of SD may not be limited to cerebral hemodynamics and metabolism but rather may also encompass changes in peripheral blood flow, possibly through a brain-heart connection, providing new insights into the role of anoxic SD in global ischemia and recovery.

Indexed as

Cerebral CortexHeart ArrestAnimalsAsphyxiaBlood PressureCerebrovascular CirculationHypoxiaMaleRatsAnoxic spreading depolarizationCardiac arrestCerebral hemodynamicsCortical spreading depolarizationNeurovascular couplingPeripheral hemodynamicsSpreading ischemia

Identifiers

PMID35729464
PMCPMC9259534
OpenAlexW4283257557

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.