Evidence map›Paper›PMID 35729367›Full record

ArticleClinical and experimental medicine2023

Ras suppressor-1 (RSU1) exerts a tumor suppressive role with prognostic significance in lung adenocarcinoma.

Sofia Nikou, Marina Arbi, Foteinos-Ioannis D Dimitrakopoulos, Argiro Kalogeropoulou, Christina Geramoutsou, Vasiliki Zolota, Haralabos P Kalofonos, Stavros Taraviras, Zoi Lygerou, Vasiliki Bravou

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Article in Clinical and experimental medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Sofia NikouDepartment of Anatomy-Histology-Embryology, Medical School, University of Patras, 26504, Patras, Greece.
Marina ArbiDepartment of General Biology, Medical School, University of Patras, 26504, Patras, Greece.
Foteinos-Ioannis D DimitrakopoulosMolecular Oncology Laboratory, Division of Oncology, Department of Medicine, Medical School, University of Patras, 26504, Patras, Greece.
Argiro KalogeropoulouDepartment of Physiology, School of Medicine, University of Patras, 26504, Rio, Patras, Greece.
Christina GeramoutsouDepartment of Anatomy-Histology-Embryology, Medical School, University of Patras, 26504, Patras, Greece.
Vasiliki ZolotaDepartment of Anatomy-Histology-Embryology, Medical School, University of Patras, 26504, Patras, Greece.
Haralabos P KalofonosMolecular Oncology Laboratory, Division of Oncology, Department of Medicine, Medical School, University of Patras, 26504, Patras, Greece.
Stavros TaravirasDepartment of Physiology, School of Medicine, University of Patras, 26504, Rio, Patras, Greece.
Zoi LygerouDepartment of General Biology, Medical School, University of Patras, 26504, Patras, Greece.
Vasiliki BravouDepartment of Anatomy-Histology-Embryology, Medical School, University of Patras, 26504, Patras, Greece. vibra@upatras.gr.ORCID http://orcid.org/0000-0002-4635-0204
University of Patras · GR

Funding

E658 K. Karatheodori Research Grant
6 · The paper itself

Abstract

Ras suppressor-1 (RSU1), originally described as a suppressor of Ras oncogenic transformation, localizes to focal adhesions interacting with the ILK-PINCH-PARVIN (IPP) complex that exerts a well-established oncogenic role in cancer. However, RSU1 implication in lung cancer is currently unknown. Our study aims to address the role of RSU1 in lung adenocarcinoma (LUADC). We here show that RSU1 protein expression by immunohistochemistry is downregulated in LUADC human tissue samples and represents a significant prognostic indicator. In silico analysis of gene chip and RNA seq data validated our findings. Depletion of RSU1 by siRNA in lung cancer cells promotes anchorage-independent cell growth, cell motility and epithelial to mesenchymal transition (EMT). Silencing of RSU1 also alters IPP complex expression in lung cancer cells. The p29 RSU1 truncated isoform is detected in lung cancer cells, and its expression is downregulated upon RSU1 silencing, whereas it is overexpressed upon ILK overexpression. These findings suggest that RSU1 exerts a tumor suppressive role with prognostic significance in LUADC.

Indexed as

Adenocarcinoma of LungLung NeoplasmsCell Line, TumorCell MovementEpithelial-Mesenchymal TransitionHumansPrognosisTranscription FactorsRSU1 protein, humanTranscription FactorsEMTLung adenocarcinomaPrognosisRas suppressor 1ΙPP complex

Identifiers

PMID35729367
OpenAlexW4283274228

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.