Evidence map›Paper›PMID 35729350›Full record

ArticleCommunications biology2022

Spontaneous pauses in firing of external pallidum neurons are associated with exploratory behavior.

Alexander Kaplan, Aviv D Mizrahi-Kliger, Pnina Rappel, Liliya Iskhakova, Gennadiy Fonar, Zvi Israel, Hagai Bergman

Open access · goldAbstract read
In one paragraph

Article in Communications biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Cognitive functions of the GPe.Trends in neurosciences · 2026
    Review
  2. Synaptic integration and competition in the substantia nigra pars reticulata-An experimental and in silico analysis.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Propagation of Oscillations in the Indirect Pathway of the Basal Ganglia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Alexander KaplanThe Edmond and Lily Safra Center for Brain Sciences, The Hebrew University, Jerusalem, Israel. alex.kaplan@mail.huji.ac.il.ORCID 0000-0002-4634-4322
Aviv D Mizrahi-KligerDepartment of Medical Neurobiology, Institute of Medical Research Israel-Canada (IMRIC), The Hebrew University-Hadassah Medical School, Jerusalem, Israel.
Pnina RappelThe Edmond and Lily Safra Center for Brain Sciences, The Hebrew University, Jerusalem, Israel.
Liliya IskhakovaThe Edmond and Lily Safra Center for Brain Sciences, The Hebrew University, Jerusalem, Israel.
Gennadiy FonarDepartment of Medical Neurobiology, Institute of Medical Research Israel-Canada (IMRIC), The Hebrew University-Hadassah Medical School, Jerusalem, Israel.
Zvi IsraelDepartment of Neurosurgery, Hadassah University Hospital, Jerusalem, Israel.
Hagai BergmanThe Edmond and Lily Safra Center for Brain Sciences, The Hebrew University, Jerusalem, Israel.ORCID 0000-0002-2402-6673
Hebrew University of Jerusalem · ILHadassah Academic College · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spontaneous pauses in firing are the hallmark of external pallidum (GPe) neurons. However, the role of GPe pauses in the basal ganglia network remains unknown. Pupil size and saccadic eye movements have been linked to attention and exploration. Here, we recorded GPe spiking activity and the corresponding pupil sizes and eye positions in non-human primates. We show that pauses, rather than the GPe discharge rate per se, were associated with dilated pupils. In addition, following pause initiation there was a considerable increase in the rate of spontaneous saccades. These results suggest that pauses are a powerful mechanism by which the GPe may influence basal ganglia downstream structures and play a role in exploratory behavior.

Indexed as

Exploratory BehaviorGlobus PallidusAnimalsBasal GangliaNeuronsSaccades

Identifiers

PMID35729350
PMCPMC9213498
OpenAlexW4283215595

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.