SynthesisClinical oral investigations2022
Tooth abnormalities associated with non-syndromic cleft lip and palate: systematic review and meta-analysis.
Synthesis in Clinical oral investigations, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 33 citations in OpenAlex.
- Factors associated with single versus multiple supernumerary teeth in a paediatric population: a cross-sectional study.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026Article
- Analysis of mandibular trabecular bone by fractal analysis in children born with oral cleft.BMC oral health · 2026Article
- Cleft lip and palate are associated with a higher prevalence of molar-incisor hypomineralisation: a cross-sectional study with a comparison group.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026Article
- Evaluating Differences in Nonsyndromic Orofacial Clefts by Infant Sex: National Birth Defects Prevention Study, 1997-2011.The Journal of pediatrics · 2026Article
- Genotype-Phenotype Correlation Insights in a Rare Case Presenting with Multiple Osteodysplastic Syndromes.Genes · 2025Article
- Nationwide Spatial Patterns and Maternal and Birth-Related Factors Associated with Orofacial Clefts in Brazil.International journal of environmental research and public health · 2025Article
- Characterization of hypomineralization second primary molar and molar incisor hypomineralization in patients with orofacial clefts.Clinical oral investigations · 2025Article
- Polymorphisms and dental age in non-syndromic cleft lip and palate: a cross-sectional study.BMC pediatrics · 2025Article
- Exploring polymorphisms in genes encoding growth factors associated with non-syndromic cleft lip with or without cleft palate and tooth agenesis.Journal of applied oral science : revista FOB · 2025Article
- Prevalence of tooth agenesis and supernumerary teeth related to different Thai cleft lip and cleft palate populations.BMC oral health · 2024Article
- Root development differences between cleft-adjacent teeth on the cleft side in comparison to their analogs on the noncleft side in patients with nonsyndromic cleft lip and palate who received secondary alveolar bone grafting.The Angle orthodontist · 2024Article
- Characterization of enamel developmental defects in patients with orofacial clefts and their relationship to surgical procedures.Clinical oral investigations · 2023Article
- Evaluation of Twenty Non-Metric Dental Crown Traits in Different Types of Malocclusions in a Sample from India, New Delhi Population.Acta stomatologica Croatica · 2023Article
- Dental caries and periodontitis risk factors in cleft lip and palate patients.Frontiers in pediatrics · 2022Review
- Instructional videos for parents/guardians of children with lip and palate clefts: integrative literature review.Jornal de pediatriaReview
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the association between orofacial clefts (OFC) and tooth abnormalities (TA).
methodsWe searched PubMed, Scopus, Web of Science, Cochrane Library, LILACS, and BBO, and in the gray literature and selected observational studies that evaluated the association between TA and OFC. The risk of bias was analyzed using the Newcastle-Ottawa Scale. A random-effects meta-analysis was performed comparing the presence and absence of OFC, cleft type-cleft palate (CP) and cleft lip with or without palate (CL/P)-and cleft laterality-unilateral and bilateral. The certainty of evidence was evaluated using the GRADE approach.
resultsA total of 99 studies were included in the qualitative analysis, and 37 were included in the meta-analysis. Only four studies were classified as low risk of bias. Significant associations were observed between the presence of OFC and tooth agenesis (OR = 19.46; 95%CI = 4.99-75.96), supernumerary teeth (OR = 4.04; 95%CI = 1.26-12.99), developmental defects of enamel (OR = 3.15; 95%CI = 1.28-7.80), microdontia (OR = 15.57; 95%CI = 1.06-228.51), and taurodontism (OR = 1.74; 95%CI = 1.74-2.86). Individuals with CP had a lower frequency of supernumerary teeth (OR = 0.22; 95%CI = 0.08-0.64), peg-shaped tooth (OR = 0.31; 95%CI = 0.12-0.80), and morphological TA (OR = 0.13; 95%CI = 0.04-0.45) than individuals with CL/P. No TA was significantly associated with cleft laterality (p > 0.05). The quality of the evidence was very low in all analyses.
conclusionIndividuals with OFC had a higher frequency of TA than those without OFC. Individuals with CP had a lower frequency of TA than individuals with CL/P. No TA was associated to cleft laterality. CLINICAL RELEVANCE: Help to identify the treatment needs of individuals affected by OFC, improving the services provided to this population.
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