Evidence map›Paper›PMID 35729228›Full record

ArticleScientific reports2022

Transmission of B.1.617.2 Delta variant between vaccinated healthcare workers.

Steven A Kemp, Mark T K Cheng, William L Hamilton, Kimia Kamelian, Indian SARS-CoV-2 Genomics Consortium (INSACOG), Sujit Singh, Partha Rakshit, Anurag Agrawal, Christopher J R Illingworth, Ravindra K Gupta

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Zoonosis and zooanthroponosis of emerging respiratory viruses.Frontiers in cellular and infection microbiology · 2023
    Review
  6. Article
  7. Article
  8. Investigation of vaccine breakthrough infections by vaccination scheme during the Delta variant wave in France.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2022
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Steven A Kemp *Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Cambridge, UK.
Mark T K Cheng *Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Cambridge, UK.
William L HamiltonDepartment of Medicine, University of Cambridge, Cambridge, UK.
Kimia KamelianNational Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada.
Indian SARS-CoV-2 Genomics Consortium (INSACOG)
Sujit SinghNational Centre for Disease Control, Delhi, India.
Partha RakshitNational Centre for Disease Control, Delhi, India.
Anurag AgrawalCSIR Institute of Genomics and Integrative Biology, Delhi, India.
Christopher J R IllingworthGarscube Campus, MRC - University of Glasgow Centre for Virus Research, 464 Bearsden Road, Glasgow, UK. christopher.illingworth@glasgow.ac.uk.
Ravindra K GuptaCambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Cambridge, UK. rkg20@cam.ac.uk.
University of Cambridge · GBNational Center for Disease Control · INInstitute of Genomics and Integrative Biology · INPublic Health Agency of Canada · CA

Funding

Gates Foundation OPP1175094Medical Research Council MC_PC_19026Medical Research Council MC_UU_12014Wellcome TrustWellcome Trust WT108082AIA
6 · The paper itself

Abstract

Breakthrough infections with SARS-CoV-2 Delta variant have been reported in doubly-vaccinated recipients and as re-infections. Studies of viral spread within hospital settings have highlighted the potential for transmission between doubly-vaccinated patients and health care workers and have highlighted the benefits of high-grade respiratory protection for health care workers. However the extent to which vaccination is preventative of viral spread in health care settings is less well studied. Here, we analysed data from 118 vaccinated health care workers (HCW) across two hospitals in India, constructing two probable transmission networks involving six HCWs in Hospital A and eight HCWs in Hospital B from epidemiological and virus genome sequence data, using a suite of computational approaches. A maximum likelihood reconstruction of transmission involving known cases of infection suggests a high probability that doubly vaccinated HCWs transmitted SARS-CoV-2 between each other and highlights potential cases of virus transmission between individuals who had received two doses of vaccine. Our findings show firstly that vaccination may reduce rates of transmission, supporting the need for ongoing infection control measures even in highly vaccinated populations, and secondly we have described a novel approach to identifying transmissions that is scalable and rapid, without the need for an infection control infrastructure.

Indexed as

COVID-19SARS-CoV-2Health PersonnelHumansInfection ControlVaccination

Identifiers

PMID35729228
PMCPMC9212198
OpenAlexW4283260526

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.