ArticleScientific reports2022
Utility of SIFT-MS to evaluate volatile organic compounds in nephropathic patients' breath.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 15 citations in OpenAlex.
- Development of a Low-Cost Portable Exhaled Breath Ammonia Detector for Supplementary Five-Stage CKD Classification Using Embedded Threshold Logic.Sensors (Basel, Switzerland) · 2026Article
- Volatomics-based biomarkers for non-invasive diagnosis and monitoring of inflammatory bowel disease.Journal of gastroenterology · 2026Article
- Recent advancements and future prospects on AI-integrated sensing techniques for non-invasive chronic kidney disease diagnosis: a review.Frontiers in artificial intelligence · 2026Review
- Evaluation of urinary volatile organic compounds as a novel metabolomic biomarker to assess chronic kidney disease progression.BMC nephrology · 2024Article
- Non-Invasive Diagnostic Approaches for Kidney Disease: The Role of Electronic Nose Systems.Sensors (Basel, Switzerland) · 2024Review
- Breath Analysis: Identification of Potential Volatile Biomarkers for Non-Invasive Diagnosis of Chronic Kidney Disease (CKD).Molecules (Basel, Switzerland) · 2024Observational
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several studies highlighted a correlation between exhaled air volatile organic compounds (VOCs) and some pathological conditions, such as chronic kidney disease (CKD), chronic liver disease, etc. In fact, in literature has been reported that CKD is characterized by an increased concentration of ammonia, trimethylamine (TMA) and isoprene compared to healthy subjects. Currently, there is not a validate and standardized method to detect VOCs. For this purpose, we examined the utility of selected ion flow tube-mass spectrometry (SIFT-MS) to measure VOCs in CKD patients and we evaluated the possible correlation between VOCs and the presence of CKD and its stage. We enrolled 68 CKD patients under conservative therapy and 54 healthy subjects. The analysis of the VOCs of the exhaled air of the enrolled subjects was performed by SIFT-MS. Among all the VOCs analyzed, the most relevant results by ROC curves were observed for TMA, acetone, ammonia and dimethyl sulfide. We found that a breath TMA concentration superior to 26 ppbv characterizes a 6.11 times greater risk of CKD, compared to subjects with lower levels. Moreover, we detected an increased concentration of acetone and ammonia in CKD patients compared to healthy subjects. We highlight the potential utility of SIFT-MS in CKD clinical management.Clinical trial registry: R.S. 15.19 of 6 February 2019.
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