ArticleScientific reports2022
Common and distinctive genomic features of Klebsiella pneumoniae thriving in the natural environment or in clinical settings.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 3 of them syntheses that pooled it.
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Who cites it
43 citing papers in PubMed, 3 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- Genetic Fingerprint ofPathogens (Basel, Switzerland) · 2026Pooled it
- Mortality risk of carbapenem-resistant hypervirulentFrontiers in public health · 2025Pooled it
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- Eco-Geography Reverses Dominant AMR Reservoirs in Klebsiella pneumoniae: Integron-Rich Mobilomes and Cross-Niche Connectivity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Whole-genome sequencing reveals high-risk ESBL and carbapenemase-producing Enterobacterales on maternity ward surfaces in Cameroon.Scientific reports · 2026Article
- Genomic architecture of fourth-generation cephalosporin-resistant Klebsiella pneumoniae Species Complex (KpSC) from patients and their hospital environment in Uganda.BMC microbiology · 2026Article
- Characterization of Proline-Rich Antimicrobial Peptides with SbmA Transporter-Dependent and Independent Antimicrobial Activity towardACS infectious diseases · 2026Article
- The acquisition ofmBio · 2026Article
- The oral cavity as a reservoir for resistance- and hypervirulence-associated genes ofFrontiers in microbiology · 2026Article
- Comprehensive genomic characterization of multidrug-resistantFrontiers in microbiology · 2026Article
- A comparative genomic approach to identify determinants of meropenem resistance inFrontiers in microbiology · 2026Article
- Hospital-Based Genomic Surveillance ofBiology · 2025Article
- The acquisition ofbioRxiv : the preprint server for biology · 2025Article
- Genomic Profiling Reveals Clinically Relevant Antimicrobial Resistance and Virulence Genes inAntibiotics (Basel, Switzerland) · 2025Article
- Genomic characterization and comparative analysis of antibiotic resistance and virulence in Bangladeshi and global Klebsiella pneumoniae ST48 strains.Journal, genetic engineering & biotechnology · 2025Article
- Harnessing Molecular and Bioactivity Network Analysis to Prioritize Antibacterial Compound Isolation From Ant-Associated Fungi.Phytochemical analysis : PCA · 2025Article
- CRISPR-Cas Dynamics in Carbapenem-Resistant and Carbapenem-SusceptiblePathogens (Basel, Switzerland) · 2025Article
- De novo virulence feature discovery and risk assessment in Klebsiella pneumoniae based on microbial genome vectorization.Communications biology · 2025Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Klebsiella pneumoniae complex is comprised of ubiquitous bacteria that can be found in soils, plants or water, and as humans' opportunistic pathogens. This study aimed at inferring common and distinctive features in clinical and environmental K. pneumoniae. Whole genome sequences of members of the K. pneumoniae complex (including K. variicola, n = 6; and K. quasipneumoniae, n = 7), of clinical (n = 78) and environmental (n = 61) origin from 21 countries were accessed from the GenBank. These genomes were compared based on phylogeny, pangenome and selected clinically relevant traits. Phylogenetic analysis based on 2704 genes of the core genome showed close relatedness between clinical and environmental strains, in agreement with the multi-locus sequence typing. Eight out of the 62 sequence types (STs) identified, included both clinical and environmental genomes (ST11, ST14, ST15, ST37, ST45, ST147, ST348, ST437). Pangenome-wide association studies did not evidence significant differences between clinical and environmental genomes. However, the genomes of clinical isolates presented significantly more exclusive genes related to antibiotic resistance/plasmids, while the environmental isolates yielded significantly higher allelic diversity of genes related with functions such as efflux or oxidative stress. The study suggests that K. pneumoniae can circulate among the natural environment and clinical settings, probably under distinct adaptation pressures.
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