Evidence map›Paper›PMID 35729182›Full record

ArticleScientific reports2022

Hilab system, a new point-of-care hematology analyzer supported by the Internet of Things and Artificial Intelligence.

Aléxia Thamara Gasparin, Claudiane Isabel Franco Araujo, Patricia Schmitt, Mônica Ribas Cardoso, Maiara Carolina Perussolo, Thainá Caroline Schuartz de Jesus, Erika Bergamo Santiago, Ivan Lucas Reis Silva, Ricardo Gurgel de Sousa, Flavia Zhu Teng and 9 more

Abstract read
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Aléxia Thamara GasparinResearch and Development Department, Hilab, Hilab Campus, José A. Possebom, 800, Curitiba, Parana, 81270-185, Brazil. alexia.gasparin@hilab.com.br.
Claudiane Isabel Franco AraujoResearch and Development Department, Hilab, Hilab Campus, José A. Possebom, 800, Curitiba, Parana, 81270-185, Brazil.
Patricia SchmittResearch and Development Department, Hilab, Hilab Campus, José A. Possebom, 800, Curitiba, Parana, 81270-185, Brazil.
Mônica Ribas CardosoResearch and Development Department, Hilab, Hilab Campus, José A. Possebom, 800, Curitiba, Parana, 81270-185, Brazil.
Maiara Carolina PerussoloResearch and Development Department, Hilab, Hilab Campus, José A. Possebom, 800, Curitiba, Parana, 81270-185, Brazil.
Thainá Caroline Schuartz de JesusResearch and Development Department, Hilab, Hilab Campus, José A. Possebom, 800, Curitiba, Parana, 81270-185, Brazil.
Erika Bergamo SantiagoResearch and Development Department, Hilab, Hilab Campus, José A. Possebom, 800, Curitiba, Parana, 81270-185, Brazil.
Ivan Lucas Reis SilvaResearch and Development Department, Hilab, Hilab Campus, José A. Possebom, 800, Curitiba, Parana, 81270-185, Brazil.
Ricardo Gurgel de SousaResearch and Development Department, Hilab, Hilab Campus, José A. Possebom, 800, Curitiba, Parana, 81270-185, Brazil.
Flavia Zhu TengResearch and Development Department, Hilab, Hilab Campus, José A. Possebom, 800, Curitiba, Parana, 81270-185, Brazil.
Evair Borges SeveroResearch and Development Department, Hilab, Hilab Campus, José A. Possebom, 800, Curitiba, Parana, 81270-185, Brazil.
Victor Henrique Alves RibeiroResearch and Development Department, Hilab, Hilab Campus, José A. Possebom, 800, Curitiba, Parana, 81270-185, Brazil.
Milena Andreuzo CardosoResearch and Development Department, Hilab, Hilab Campus, José A. Possebom, 800, Curitiba, Parana, 81270-185, Brazil.
Fernanda D'Amico SilvaResearch and Development Department, Hilab, Hilab Campus, José A. Possebom, 800, Curitiba, Parana, 81270-185, Brazil.
Carolina Rodrigues de Araujo PerazzoliResearch and Development Department, Hilab, Hilab Campus, José A. Possebom, 800, Curitiba, Parana, 81270-185, Brazil.
João Samuel de Holanda FariasErasto Gaertner Hospital, Ovande do Amaral, 201, Parana, Brazil.
Bernardo Montesanti Machado de AlmeidaResearch and Development Department, Hilab, Hilab Campus, José A. Possebom, 800, Curitiba, Parana, 81270-185, Brazil.
Sergio Renato Rogal JúniorResearch and Development Department, Hilab, Hilab Campus, José A. Possebom, 800, Curitiba, Parana, 81270-185, Brazil.
Marcus Vinícius Mazega FigueredoResearch and Development Department, Hilab, Hilab Campus, José A. Possebom, 800, Curitiba, Parana, 81270-185, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The complete blood count (CBC) is one of the most requested tests by physicians. CBC tests, most realized in conventional hematological analyzers, are restricted to centralized laboratories due to frequent maintenance, large devices, and expensive costs required. On the other hand, most handheld CBC devices commercially available show high prices and are not liable to calibration or control procedures, which results in poor quality compared to standard hematology instruments. The Hilab system is a small-handed hematological platform that uses microscopy and chromatography techniques for blood cells and hematimetric parameters analysis through artificial intelligence, machine learning, and deep learning techniques. For clinical evaluation of the handheld CBC device, 450 blood samples were analyzed. The samples encompassed normal (82%) and pathological conditions (18%), such as thalassemias (2.2%), anemias (6.6%), and infections (9.2%). For all analytes, accuracy, precision, method comparison, and flagging capabilities of the Hilab System, were compared with the Sysmex XE-2100 (Sysmex, Japan) results. The sample source (venous and capillary) influences were also evaluated. Pearson correlation, Student t test, bias, and the Bland-Altman plot of each blood count analyte were calculated and shown. The significance level was set at p ≤ 0.05. For clinical evaluation, Hilab System and the Sysmex XE-2100 showed a strong correlation (r ≥ 0.9) for most evaluated parameters. In the precision study, analytes showed CV inside the limits established according to European Federation of Clinical Chemistry and Laboratory Medicine guidelines. The flagging capabilities of the Hilab system, compared to the manual microscopy technique, presented high sensibility, specificity, and accuracy. Venous and capillary samples (p > 0.05) do not differ statistically. Considering the need for point-of-care CBCs, the study indicated that the Hilab system provides fast, accurate, low cost, and robust analysis for reliable clinical use.

Indexed as

HematologyInternet of ThingsArtificial IntelligenceBlood Cell CountHumansPoint-of-Care SystemsReproducibility of Results

Identifiers

PMID35729182
PMCPMC9213419

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.