ArticleNature communications2022
A trefoil knot self-templated through imination in water.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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Who cites it
16 citing papers in PubMed.
- "Click" formation of the imine bond in water.Chemical science · 2026Article
- Facile Preparation of a Poly[2]Catenane Network Using Self-Assembled [2]Catenane Unit.Angewandte Chemie (International ed. in English) · 2026Article
- Stereoselective Synthesis of Topologically Chiral Knots and Links: Synthesis and Applications.Molecules (Basel, Switzerland) · 2026Review
- Template-directed vertical photopolymerization for construction of triphenylamine-based poly(diacetylene) nanofibers.Nature communications · 2026Article
- A self-assembled macrocycle with a non-closed structure for hierarchically upgraded self-assembly.Chemical science · 2026Article
- Observation of Near-Infrared Photothermal and Photoacoustic Effects in a Metallosupramolecular Trefoil Knot.Angewandte Chemie (International ed. in English) · 2025Article
- Effective RNA Complexation by [2]Catenanes Confers Enhanced Resistance to Enzymatic Degradation.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Generation and characteristics analysis of the overhand knot using co-screw as gene.Scientific reports · 2025Article
- Template-directed self-assembly of porphyrin nanorings through an imine condensation reaction.Chemical science · 2025Article
- Charge-transfer complexation of coordination cages for enhanced photochromism and photocatalysis.Nature communications · 2025Article
- Phosphorescent metallaknots of Au(I)-bis(acetylide) strands directed by Cu(I) π-coordination.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Key structural features to favour imines over hydrates in water: pyridoxal phosphate as a muse.Chemical science · 2024Article
- Solid-State Self-Assembly: Exclusive Formation and Dynamic Interconversion of Discrete Cyclic Assemblies Based on Molecular Tweezers.The Journal of organic chemistry · 2024Article
- Dynamic Chemistry Toolbox for Advanced Sustainable Materials.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Dynamic covalent synthesis.Chemical science · 2024Review
- Supramolecular multivalency effects enhance imine formation in aqueous medium allowing for dynamic modification of enzymatic activity.Chemical science · 2023Article
Corrections and comments
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The preparation of topologically nontrivial molecules is often assisted by covalent, supramolecular or coordinative templates that provide spatial pre-organization for all components. Herein, we report a trefoil knot that can be self-assembled efficiently in water without involving additional templates. The direct condensation of three equivalents of a tetraformyl precursor and six equivalents of a chiral diamine produces successfully a [3 + 6] trefoil knot whose intrinsic handedness is dictated by the stereochemical configuration of the diamine linkers. Contrary to the conventional wisdom that imine condensation is not amenable to use in water, the multivalent cooperativity between all the imine bonds within the framework makes this trefoil knot robust in the aqueous environment. Furthermore, the presence of water is proven to be essential for the trefoil knot formation. A topologically trivial macrocycle composed of two tetraformyl and four diamino building blocks is obtained when a similar reaction is performed in organic media, indicating that hydrophobic effect is a major driving force behind the scene.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.