Evidence map›Paper›PMID 35729081›Full record

ArticleJournal of neuroimaging : official journal of the American Society of Neuroimaging2022

Limited utility of structural MRI to identify the epileptogenic zone in young children with tuberous sclerosis.

Maaike Nijman, Edward Yang, Camilo Jaimes, Anna K Prohl, Mustafa Sahin, Darcy A Krueger, Joyce Y Wu, Hope Northrup, Scellig S D Stone, Joseph R Madsen and 10 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroimaging : official journal of the American Society of Neuroimaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 9 institutions in 1 country.

Maaike NijmanLocalization Laboratory, Division of Epilepsy and Clinical Neurophysiology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0001-9665-0291
Edward YangDepartment of Radiology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Camilo JaimesDepartment of Radiology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Anna K ProhlComputational Radiology Laboratory, Department of Radiology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Mustafa SahinRosamund Stone Zander Translational Neuroscience Center, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Darcy A KruegerDivision of Neurology, Cincinnati Children's Hospital Medical Center, and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Joyce Y WuDivision of Neurology, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, USA.
Hope NorthrupDepartment of Pediatrics, McGovern Medical School, at University of Texas Health Science Center at Houston (UTHealth) and Children's Memorial Hermann Hospital, Houston, Texas, USA.
Scellig S D StoneDepartment of Neurosurgery, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Joseph R MadsenDepartment of Neurosurgery, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Aria FallahDepartment of Neurosurgery, Division of Pediatric Neurosurgery, University of California Los Angeles Mattel Children's Hospital, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA.
Jeffrey P BlountDepartment of Neurosurgery, Division of Pediatric Neurosurgery, Children's of Alabama, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Howard L WeinerDepartment of Surgery, Division of Pediatric Neurosurgery, Texas Children's Hospital, Houston, Texas, USA.
Leslie GraysonDepartment of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
E Martina BebinDepartment of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Brenda E PorterDepartment of Neurology, Stanford University Medical Center, Stanford, California, USA.
Simon K WarfieldRosamund Stone Zander Translational Neuroscience Center, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Sanjay P PrabhuDepartment of Radiology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Jurriaan M PetersLocalization Laboratory, Division of Epilepsy and Clinical Neurophysiology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
TACERN Study Group
Boston Children's Hospital · USUniversity of Alabama at Birmingham · USBaylor College of Medicine · USChildren's of Alabama · USCincinnati Children's Hospital Medical Center · USMemorial Hermann · USNorthwestern University · USStanford Medicine · USUniversity of California, Los Angeles · US

Funding

Early Biomarkers of Autism Spectrum Disorders in infants with Tuberous SclerosisU01NS082320 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI KRUEGER, DARCY, SAHIN, MUSTAFA · 2012 to 2018
$13.3M
NINDS NIH HHS U01 NS082320
6 · The paper itself

Abstract

background and purposeThe success of epilepsy surgery in children with tuberous sclerosis complex (TSC) hinges on identification of the epileptogenic zone (EZ). We studied structural MRI markers of epileptogenic lesions in young children with TSC.

methodsWe included 26 children with TSC who underwent epilepsy surgery before the age of 3 years at five sites, with 12 months or more follow-up. Two neuroradiologists, blinded to surgical outcome data, reviewed 10 candidate lesions on preoperative MRI for characteristics of the tuber (large affected area, calcification, cyst-like properties) and of focal cortical dysplasia (FCD) features (cortical malformation, gray-white matter junction blurring, transmantle sign). They selected lesions suspect for the EZ based on structural MRI, and reselected after unblinding to seizure onset location on electroencephalography (EEG).

resultsNone of the tuber characteristics and FCD features were distinctive for the EZ, indicated by resected lesions in seizure-free children. With structural MRI alone, the EZ was identified out of 10 lesions in 31%, and with addition of EEG data, this increased to 48%. However, rates of identification of resected lesions in non-seizure-free children were similar. Across 251 lesions, interrater agreement was moderate for large size (κ = .60), and fair (κ = .24) for all other features.

conclusionsIn young children with TSC, the utility of structural MRI features is limited in the identification of the epileptogenic tuber, but improves when combined with EEG data.

Indexed as

EpilepsyMalformations of Cortical DevelopmentTuberous SclerosisChildChild, PreschoolElectroencephalographyHumansMagnetic Resonance ImagingRetrospective StudiesTreatment Outcomechildrenepilepsyepilepsy surgeryMRItuberous sclerosis complex

Identifiers

PMID35729081
PMCPMC11267633
OpenAlexW4283270738

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.