Evidence map›Paper›PMID 35728922›Full record

ArticleJournal of psychiatry & neuroscience : JPN

Identifying common and distinct subcortical volumetric abnormalities in 3 major psychiatric disorders: a single-site analysis of 640 participants.

Pei-Chi Tu, Wan-Chen Chang, Mu-Hong Chen, Ju-Wei Hsu, Wei-Chen Lin, Cheng-Ta Li, Tung-Ping Su, Ya-Mei Bai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of psychiatry & neuroscience : JPN. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
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  4. Motor Functional Hierarchical Organization of Cerebrum and Its Underlying Genetic Architecture in Parkinson's Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
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  6. Review
  7. Increased [Journal of neurotrauma · 2024
    Article
  8. Article
  9. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Pei-Chi TuFrom the Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan (Tu, Chang); the Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan (Tu, Chang, Chen, Hsu, Lin, Li, Bai); the Institute of Philosophy of Mind and Cognition, National Yang Ming Chiao Tung University, Taipei, Taiwan (Tu); the Department of Psychiatry, Faculty of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan (Tu, Chen, Hsu, Lin, Li, Su, Bai); the Department of Biomedical Engineering, National Yang Ming Chiao Tung University, Taipei, Taiwan (Chang); the Institute of Brain Science, National Yang Ming Chiao Tung University, Taipei, Taiwan (Lin, Li, Su, Bai); the Department of Psychiatry, Cheng Hsin General Hospital, Taipei, Taiwan (Su).
Wan-Chen ChangFrom the Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan (Tu, Chang); the Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan (Tu, Chang, Chen, Hsu, Lin, Li, Bai); the Institute of Philosophy of Mind and Cognition, National Yang Ming Chiao Tung University, Taipei, Taiwan (Tu); the Department of Psychiatry, Faculty of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan (Tu, Chen, Hsu, Lin, Li, Su, Bai); the Department of Biomedical Engineering, National Yang Ming Chiao Tung University, Taipei, Taiwan (Chang); the Institute of Brain Science, National Yang Ming Chiao Tung University, Taipei, Taiwan (Lin, Li, Su, Bai); the Department of Psychiatry, Cheng Hsin General Hospital, Taipei, Taiwan (Su).
Mu-Hong ChenFrom the Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan (Tu, Chang); the Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan (Tu, Chang, Chen, Hsu, Lin, Li, Bai); the Institute of Philosophy of Mind and Cognition, National Yang Ming Chiao Tung University, Taipei, Taiwan (Tu); the Department of Psychiatry, Faculty of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan (Tu, Chen, Hsu, Lin, Li, Su, Bai); the Department of Biomedical Engineering, National Yang Ming Chiao Tung University, Taipei, Taiwan (Chang); the Institute of Brain Science, National Yang Ming Chiao Tung University, Taipei, Taiwan (Lin, Li, Su, Bai); the Department of Psychiatry, Cheng Hsin General Hospital, Taipei, Taiwan (Su).
Ju-Wei HsuFrom the Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan (Tu, Chang); the Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan (Tu, Chang, Chen, Hsu, Lin, Li, Bai); the Institute of Philosophy of Mind and Cognition, National Yang Ming Chiao Tung University, Taipei, Taiwan (Tu); the Department of Psychiatry, Faculty of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan (Tu, Chen, Hsu, Lin, Li, Su, Bai); the Department of Biomedical Engineering, National Yang Ming Chiao Tung University, Taipei, Taiwan (Chang); the Institute of Brain Science, National Yang Ming Chiao Tung University, Taipei, Taiwan (Lin, Li, Su, Bai); the Department of Psychiatry, Cheng Hsin General Hospital, Taipei, Taiwan (Su).
Wei-Chen LinFrom the Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan (Tu, Chang); the Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan (Tu, Chang, Chen, Hsu, Lin, Li, Bai); the Institute of Philosophy of Mind and Cognition, National Yang Ming Chiao Tung University, Taipei, Taiwan (Tu); the Department of Psychiatry, Faculty of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan (Tu, Chen, Hsu, Lin, Li, Su, Bai); the Department of Biomedical Engineering, National Yang Ming Chiao Tung University, Taipei, Taiwan (Chang); the Institute of Brain Science, National Yang Ming Chiao Tung University, Taipei, Taiwan (Lin, Li, Su, Bai); the Department of Psychiatry, Cheng Hsin General Hospital, Taipei, Taiwan (Su).
Cheng-Ta LiFrom the Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan (Tu, Chang); the Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan (Tu, Chang, Chen, Hsu, Lin, Li, Bai); the Institute of Philosophy of Mind and Cognition, National Yang Ming Chiao Tung University, Taipei, Taiwan (Tu); the Department of Psychiatry, Faculty of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan (Tu, Chen, Hsu, Lin, Li, Su, Bai); the Department of Biomedical Engineering, National Yang Ming Chiao Tung University, Taipei, Taiwan (Chang); the Institute of Brain Science, National Yang Ming Chiao Tung University, Taipei, Taiwan (Lin, Li, Su, Bai); the Department of Psychiatry, Cheng Hsin General Hospital, Taipei, Taiwan (Su).
Tung-Ping SuFrom the Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan (Tu, Chang); the Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan (Tu, Chang, Chen, Hsu, Lin, Li, Bai); the Institute of Philosophy of Mind and Cognition, National Yang Ming Chiao Tung University, Taipei, Taiwan (Tu); the Department of Psychiatry, Faculty of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan (Tu, Chen, Hsu, Lin, Li, Su, Bai); the Department of Biomedical Engineering, National Yang Ming Chiao Tung University, Taipei, Taiwan (Chang); the Institute of Brain Science, National Yang Ming Chiao Tung University, Taipei, Taiwan (Lin, Li, Su, Bai); the Department of Psychiatry, Cheng Hsin General Hospital, Taipei, Taiwan (Su) ymbi@mail2000.com.tw tomsu0402@gmail.com.
Ya-Mei BaiFrom the Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan (Tu, Chang); the Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan (Tu, Chang, Chen, Hsu, Lin, Li, Bai); the Institute of Philosophy of Mind and Cognition, National Yang Ming Chiao Tung University, Taipei, Taiwan (Tu); the Department of Psychiatry, Faculty of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan (Tu, Chen, Hsu, Lin, Li, Su, Bai); the Department of Biomedical Engineering, National Yang Ming Chiao Tung University, Taipei, Taiwan (Chang); the Institute of Brain Science, National Yang Ming Chiao Tung University, Taipei, Taiwan (Lin, Li, Su, Bai); the Department of Psychiatry, Cheng Hsin General Hospital, Taipei, Taiwan (Su) ymbi@mail2000.com.tw tomsu0402@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSubcortical volumetric abnormalities in schizophrenia, bipolar disorder and major depressive disorder (MDD) have been consistently found on a single-diagnosis basis in previous studies. However, whether such volumetric abnormalities are specific to a particular disorder or shared by other disorders remains unclear.

methodsWe analyzed the structural MRIs of 160 patients with schizophrenia, 160 patients with bipolar disorder, 160 patients with MDD and 160 healthy controls. We calculated the volumes of the thalamus, hippocampus, amygdala, accumbens, putamen, caudate, pallidum and lateral ventricles using FreeSurfer 7.0 and compared them among the groups using general linear models.

resultsWe found a significant group effect on the volumes of the thalamus, hippocampus, accumbens and pallidum. Further post hoc analysis revealed that thalamic volumes in patients with schizophrenia, bipolar disorder and MDD were significantly reduced compared to those in healthy controls, but did not differ from one another. Patients with schizophrenia and bipolar disorder also shared a significant reduction in hippocampal volumes. Among the 3 clinical groups, patients with schizophrenia showed significantly lower hippocampal volumes and higher pallidal volumes than patients with bipolar disorder and MDD. LIMITATIONS: Differences in psychotropic use and duration of illness among the patient groups may limit the interpretation of our findings.

conclusionOur findings indicate that decreased thalamic volume is a common feature of schizophrenia, bipolar disorder and MDD. Smaller hippocampal and larger pallidal volumes differentiate schizophrenia from bipolar disorder and MDD and may provide clues to the biological basis for the Kraepelinian distinction between these illnesses.

Indexed as

Bipolar DisorderMajor Depressive DisorderSchizophreniaHippocampusHumansMagnetic Resonance ImagingPutamen

Identifiers

PMID35728922
PMCPMC9343126

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