ArticleOpen heart2022
Progression of aortic stenosis after an acute myocardial infarction.
Article in Open heart, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 6 citations in OpenAlex.
- Diastolic dysfunction is linked to the initiation and progression of aortic stenosis: a hypothesis.European heart journal · 2026Review
- Value of Color Doppler Echocardiography for Predicting Heart Failure After Percutaneous Coronary Intervention in Patients with Acute Myocardial Infarction.International journal of general medicine · 2026Article
- Plasma levels of NO-related pathway molecules to predict post-transcatheter aortic valve implantation major adverse cardiovascular events: a prospective, multicenter study.Postepy w kardiologii interwencyjnej = Advances in interventional cardiology · 2025Article
- Impact of cardiovascular comorbidities on echocardiographic parameters in aortic stenosis.Postepy w kardiologii interwencyjnej = Advances in interventional cardiology · 2025Article
- The impact of pre-existing aortic stenosis and mitral regurgitation on patients with acute myocardial infarction.Scientific reports · 2025Article
- The role of pre-existing left-sided valvular heart disease in the prognosis of patients with acute myocardial infarction.Frontiers in cardiovascular medicine · 2024Review
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundMyocardial infarction (MI) has been shown to induce fibrotic remodelling of the mitral and tricuspid valves. It is unknown whether MI also induces pathological remodelling of the aortic valve and alters aortic stenosis (AS) progression. We thus compared AS progression after an acute MI and in patients with/without history of MI, and assessed post-MI pathobiological changes within the aortic valve leaflets in a sheep model.
methodsSerial echocardiograms in human patients with AS were retrospectively analysed and compared between 3 groups: (1) acute MI at baseline (n=68), (2) prior history of MI (n=45) and (3) controls without MI (n=101). Annualised progression rates of AS severity were compared between these 3 groups. In addition, aortic valves were harvested from 15 sheep: (1) induced inferior MI (n=10) and (2) controls without MI (n=5), for biological and histological analyses.
resultsIn humans, the acute MI, previous MI and control groups had comparable baseline AS severity. Indexed aortic valve area (AVA
conclusionsThe results of this study suggest that AS progression is accelerated following acute MI, which could be caused by increased collagen production and thickening of the aortic valve after the ischaemic event.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.