Evidence map›Paper›PMID 35728781›Full record

Trial reportAmerican journal of obstetrics & gynecology MFM2022

Antibiotic Prophylaxis to Prevent Obesity-Related Induction Complications in Nulliparae at Term: a pilot randomized controlled trial.

Stephanie L Pierce, Jennifer D Peck, Christy Zornes, Elizabeth Standerfer, Rodney K Edwards

Registry-linked trialOpen access · greenAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in American journal of obstetrics & gynecology MFM, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06543290 (Azithromycin to Prevent Chorioamnionitis in Women Undergoing Induction of Labor, a Randomized Control Trial), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06543290 phase1recruitingnot on this mapstarted 2023, after this paper: background citation

Azithromycin to Prevent Chorioamnionitis in Women Undergoing Induction of Labor, a Randomized Control Trial

TypeinterventionalSponsorArrowhead Regional Medical CenterRan2023 to 2026Enrolled400ConditionsInfectionsArmsAzithromycin Pill, Placebo
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Stephanie L PierceSection of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, The University of Oklahoma College of Medicine, Oklahoma City, OK. Electronic address: stephanieboespierce@gmail.com.
Jennifer D PeckSection of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, The University of Oklahoma College of Medicine, Oklahoma City, OK; Department of Biostatistics and Epidemiology, Hudson College of Public Health, The University of Oklahoma Health Science Center, Oklahoma City, OK.
Christy ZornesSection of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, The University of Oklahoma College of Medicine, Oklahoma City, OK.
Elizabeth StanderferSection of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, The University of Oklahoma College of Medicine, Oklahoma City, OK.
Rodney K EdwardsSection of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, The University of Oklahoma College of Medicine, Oklahoma City, OK.
University of Oklahoma · USUniversity of Oklahoma Health Sciences Center · US

Funding

Tracking and Evaluation CoreU54GM104938 · NIGMS · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Robert Hal Scofield · 2013 to 2026
$68.2M
NIGMS NIH HHS U54 GM104938
6 · The paper itself

Abstract

backgroundWomen with obesity are at increased risk of complications during and after labor and delivery, including puerperal infection and cesarean delivery. As labor induction has become increasingly common, it is crucial to find ways to decrease complication rates in this high-risk population.

objectiveThis study aimed to explore the effect of prophylactic antibiotics during labor induction of nulliparous women with obesity on the rates of cesarean delivery and puerperal infection and to estimate the parameters needed to calculate the sample size for a larger, multicenter trial. STUDY

designIn this randomized, placebo-controlled pilot trial, nulliparous patients with a body mass index of ≥30 kg/m

resultsFrom January 2019 to May 2021, 101 patients were randomized in the class III stratum (1 patient who was randomized ultimately did not undergo labor induction). From February 2020 to May 2021, 38 and 47 patients were randomized to class I and II strata, respectively (to assess the effect of obesity class on the outcomes expected to be influenced by antibiotic prophylaxis). In the antibiotics and placebo groups, the rates of cesarean delivery were 29.0% (95% confidence interval, 19.8-38.3) and 39.8% (95% confidence interval, 29.8-49.7), respectively, and puerperal infection occurred in 8.6% (95% confidence interval, 2.9-14.3) and 9.7% (95% confidence interval, 3.7-15.7), respectively. In the subgroup with class III obesity, in the antibiotics and placebo groups, the rates of cesarean delivery were 33.3% (95% confidence interval, 20.4-47.9) and 46.0% (95% confidence interval, 32.2-59.8), respectively, and puerperal infection occurred in 7.8% (95% confidence interval, 0.5-15.2) and 10.0% (95% confidence interval, 1.7-18.3), respectively. Note that this pilot study was not powered to detect differences of this magnitude but rather to estimate parameters.

conclusionThe administration of prophylactic antibiotics during labor induction of nulliparous patients with obesity resulted in a 27% lower cesarean delivery rate overall and a 28% lower rate in patients with class III obesity. A larger trial is warranted to evaluate these differences.

Indexed as

Antibiotic ProphylaxisPuerperal InfectionAnti-Bacterial AgentsAzithromycinFemaleHumansInfant, NewbornObesityPilot ProjectsPregnancyAnti-Bacterial AgentsAzithromycincesareancesarean delivery ratechorioamnionitisendometritislabor inductionobeseobesitypilot studypuerperal infectionwound infection

Identifiers

PMID35728781
PMCPMC9611553
OpenAlexW4283075050

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.