Evidence map›Paper›PMID 35728613›Full record

ArticleEuropean journal of dentistry2023

Gingival Mesenchymal Stem Cells Metabolite Decreasing TRAP, NFATc1, and Sclerostin Expression in LPS-Associated Inflammatory Osteolysis In Vivo.

Alexander Patera Nugraha, Nastiti Faradilla Ramadhani, Wibi Riawan, Igo Syaiful Ihsan, Diah Savitri Ernawati, Rini Devijanti Ridwan, Ida Bagus Narmada, Tania Saskianti, Fianza Rezkita, Andari Sarasati and 4 more

Open access · hybridAbstract read
In one paragraph

Article in European journal of dentistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Alexander Patera NugrahaDental Regenerative Research Group, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
Nastiti Faradilla RamadhaniDental Regenerative Research Group, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
Wibi RiawanDepartment of Biomolecular Biochemistry, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia.
Igo Syaiful IhsanStem Cell Research and Development Center, Universitas Airlangga Surabaya, Surabaya, Indonesia.
Diah Savitri ErnawatiDepartment of Oral Medicine, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
Rini Devijanti RidwanDepartment of Oral Biology, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
Ida Bagus NarmadaDental Regenerative Research Group, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
Tania SaskiantiDepartment of Pediatric Dentistry, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
Fianza RezkitaFaculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
Andari SarasatiFaculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
Tengku Natasha Eleena Binti Tengku Ahmad NoorMembership Faculty of Dental Surgery, Royal Collage of Surgery, Edinburgh University, UK.
Bilqis InayatillahDepartment of Basic Medical of Science, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
Albertus Putera NugrahaFaculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
Florentina JoestandariFaculty of Dentistry, Institute of Health Bhakti Wiyata, Kediri, Indonesia.
Airlangga University · IDInstitut Ilmu Kesehatan Bhakti Wiyata · IDRoyal College of Surgeons of Edinburgh · GBUniversity of Brawijaya · ID

Funding

212/UN3/2021 Hibah Internal Penelitian Dosen Pemula (PDP)Hibah Internal Penelitian Dosen Pemula (PDP) 212/UN3/2021
6 · The paper itself

Abstract

objectiveBone is a dynamic tissue that undergoes remodeling. During bone remodeling, there are transcription factors such as nuclear factor-activated T cells-1 (NFATc1), sclerostin, and tartrate-resistant acid phosphatase (TRAP) that are released for bone resorption. Metabolite from gingival mesenchymal stem cells (GMSCs) has the ability to activate proliferation, migration, immunomodulation, and tissue regeneration of bone cells and tissues. Furthermore, the aim of this study is to investigate the metabolite of GMSCs' effect on expression of NFATc1, TRAP, and sclerostin in calvaria bone resorption of Wistar rats. MATERIALS AND

methodsTwenty male healthy Wistar rats ( STATISTICAL ANALYSIS: One-way analysis of variance and Tukey honest significant different were conducted to analyze differences between groups (

resultsThe administration of GMSCs metabolite can significantly decrease TRAP, NFATc1, and sclerostin expression (

conclusionGMSCs metabolite decrease TRAP, NFATc1, and sclerostin expression in LPS-associated osteolysis calvaria in Wistar rats (

Identifiers

PMID35728613
PMCPMC10569879
OpenAlexW4283266897

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.