ArticleDiabetes/metabolism research and reviews2022
Uric acid versus metabolic syndrome as markers of fatty liver disease in young people with overweight/obesity.
Article in Diabetes/metabolism research and reviews, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 25 citations in OpenAlex.
- Prevalence of non-alcoholic fatty liver disease and its association with different combinations of weight status and metabolic abnormalities in children aged 6-18 years.Pediatric investigation · 2026Article
- Pediatric hyperuricemia: genetic basis, metabolic mechanisms, and clinical implications.Frontiers in endocrinology · 2026Review
- The association of serum uric acid level and the uric acid to creatinine ratio with non alcoholic fatty liver disease in children with obesity.Scientific reports · 2025Article
- Serum uric acid trajectories and risk of metabolic dysfunction-associated steatotic liver disease in China: a 2019-2021 cohort health survey.BMC public health · 2025Article
- Web of Science-Based Visualization of Metabolic Dysfunction-Associated Fatty Liver Disease in Pediatric and Adolescent Populations: A Bibliometric Study.Health science reports · 2025Article
- Nonlinear Association Between Serum Uric Acid and Femoral Neck Bone Mineral Density in Male Patients with Metabolic Dysfunction-Associated Fatty Liver Disease.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Prediction of insulin resistance and elevated liver transaminases using serum uric acid and derived markers in children and adolescents.European journal of clinical nutrition · 2024Article
- Xanthine oxidase promotes hepatic lipid accumulation through high fat absorption by the small intestine.JHEP reports : innovation in hepatology · 2024Article
- Association of serum uric acid with hypertriglyceridemia in children and adolescents: a cross-sectional study.Lipids in health and disease · 2024Article
- Sex-Related Differences in Cardiovascular Risk in Adolescents with Overweight or Obesity.Reviews in cardiovascular medicine · 2024Article
- Association between serum uric acid-to-high-density lipoprotein cholesterol ratio and metabolic dysfunction-associated steatotic liver disease among Chinese children with obesity.Frontiers in endocrinology · 2024Article
- Skeptical Look at the Clinical Implication of Metabolic Syndrome in Childhood Obesity.Children (Basel, Switzerland) · 2023Review
- Is Metabolic Syndrome Useful for Identifying Youths with Obesity at Risk for NAFLD?Children (Basel, Switzerland) · 2023Article
- Uric acid versus metabolic syndrome as markers of fatty liver disease in young people with overweight/obesity.Diabetes/metabolism research and reviews · 2022Article
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Authors and funding
11 authors at 8 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo compare the association of high serum uric acid (HUA) or metabolic syndrome (MetS) with fatty liver disease (FLD) in youths with overweight/obesity (OW/OB). MATERIALS AND
methodsCross-sectional study of anthropometrics, biochemical variables, and liver ultrasound of 3104 individuals with OW/OB (age 5-17 years). Metabolic syndrome was defined by ≥ 3 criteria among (1) high waist circumference; (2) high triglycerides; (3) low high-density lipoproteins; (4) fasting glucose ≥100 mg/dl; (5) blood pressure ≥95
resultsThe sample was stratified in four categories: (1) no HUA, no MetS (reference category); (2) MetS; (3) HUA; (4) HUA and MetS (HUA + MetS). The prevalence of FLD increased across the four categories from 29.9%, 44.0%, 52.2%, to 67.1%, respectively (p < 0.0001). The ORs for the categorical variables were 1.33 (1.06-1.68) for MetS (p = 0.02), 3.19 (2.51-4.05) for HUA (p < 0.0001) and 3.72 (2.65-5.21) for HUA + MetS (p < 0.0001), versus the reference category regardless of the body mass index.
conclusionsHUA represents a useful marker of FLD in youths with OW/OB, given its greater ability to identify those at increased risk of the disease compared to MetS. The ability of both to predict incident FLD must be investigated in longitudinal study.
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