ArticleProceedings of the National Academy of Sciences of the United States of America2022
Temporally and anatomically specific contributions of the human amygdala to threat and safety learning.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
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Who cites it
45 citing papers in PubMed, 66 citations in OpenAlex.
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- A double-blind trial of decoded neurofeedback intervention for specific phobias.Psychiatry and clinical neurosciences · 2024Trial
- Nicotine reduces discrimination between threat and safety in the hippocampus, nucleus accumbens and amygdala.Translational psychiatry · 2024Trial
- Oxytocin effects on amygdala reactivity to angry faces in males and females with antisocial personality disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Trial
- Dopamine D2/3 receptors and functional connectivity during fear extinction: A PET-fMRI study.Neuroimage. Reports · 2026Article
- Opposing sensitive period effects of early and late childhood maltreatment on corticolimbic responses in fear conditioning.Molecular psychiatry · 2026Article
- Dynamic changes in amygdala and insula responses to the onset and offset of conditioned stimuli during threat learning.Scientific reports · 2026Article
- Effect of emotion on hippocampal-dependent associative binding through the lens of the weather prediction task.Cognitive, affective & behavioral neuroscience · 2026Article
- Amygdala transcranial ultrasound stimulation disrupts threat acquisition and extinction learning.Science advances · 2026Review
- The human amygdala in threat learning and extinction.Science advances · 2026Article
- Ventromedial prefrontal cortex activity during extinction recall suggests successful extinction learning via mental imagery.Social cognitive and affective neuroscience · 2026Article
- Higher-order statistics for constructing centered edge functional connectivity.Network neuroscience (Cambridge, Mass.) · 2026Article
- Investigating the functional neural network dynamics of cognitive-affective action planning during threat processing.Frontiers in psychology · 2026Article
- Lasting effects of oral contraceptives on fear responses to a safe context.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Altered Functional Connectivity of Amygdala Subregions with Large-Scale Brain Networks in Schizophrenia: A Resting-State fMRI Study.Tomography (Ann Arbor, Mich.) · 2025Article
- Neural correlates of human fear conditioning and sources of variability in 2199 individuals.Nature communications · 2025Article
- Associative coding of conditioned fear in the thalamic nucleus reuniens in rodents and humans.Communications biology · 2025Article
- Neural Representation of Associative Threat Learning in Pulvinar Divisions, Lateral Geniculate Nucleus, and Mediodorsal Thalamus in Humans.bioRxiv : the preprint server for biology · 2025Article
- Developmental Differences in a Hippocampal-Cingulate Pathway Involved in Learned Safety Following Interpersonal Trauma Exposure.Journal of the American Academy of Child and Adolescent Psychiatry · 2025Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Neural plasticity in subareas of the rodent amygdala is widely known to be essential for Pavlovian threat conditioning and safety learning. However, less consistent results have been observed in human neuroimaging studies. Here, we identify and test three important factors that may contribute to these discrepancies: the temporal profile of amygdala response in threat conditioning, the anatomical specificity of amygdala responses during threat conditioning and safety learning, and insufficient power to identify these responses. We combined data across multiple studies using a well-validated human threat conditioning paradigm to examine amygdala involvement during threat conditioning and safety learning. In 601 humans, we show that two amygdala subregions tracked the conditioned stimulus with aversive shock during early conditioning while only one demonstrated delayed responding to a stimulus not paired with shock. Our findings identify cross-species similarities in temporal- and anatomical-specific amygdala contributions to threat and safety learning, affirm human amygdala involvement in associative learning and highlight important factors for future associative learning research in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.