Evidence map›Paper›PMID 35727973›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Brain tract structure predicts relapse to stimulant drug use.

Loreen Tisdall, Kelly H MacNiven, Claudia B Padula, Josiah K Leong, Brian Knutson

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Females have shorter scalp-to-cortex distances and receive stronger TMS electrical fields: Implications for clinical treatment.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  5. Article
  6. Article
  7. Neuroimaging Biomarkers in Addiction.medRxiv : the preprint server for health sciences · 2024
    Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Loreen TisdallCenter for Cognitive and Decision Sciences, University of Basel, 4055 Basel, Switzerland.ORCID 0000-0001-6303-6148
Kelly H MacNivenDepartment of Psychology, Stanford University, Stanford, CA 94305-2130.ORCID 0000-0002-9437-7815
Claudia B PadulaVA Palo Alto Health Care System, Palo Alto, CA 94304.ORCID 0000-0002-0574-9374
Josiah K LeongDepartment of Psychological Science, University of Arkansas, Fayetteville, AR 72701.ORCID 0000-0002-2760-7289
Brian KnutsonDepartment of Psychology, Stanford University, Stanford, CA 94305-2130.ORCID 0000-0002-7669-426X
Stanford University · USUniversity of Arkansas at Fayetteville · USUniversity of Basel · CHVA Palo Alto Health Care System · US

Funding

Training CoreP50DA042012 · NIDA · STANFORD UNIVERSITY · PI Karl A. Deisseroth · 2017 to 2026
$27.1M
Neural Circuitry Underlying Alcohol Use Disorders in Men and Women VeteransIK2CX001356 · VA · VETERANS ADMIN PALO ALTO HEALTH CARE SYS · PI PADULA, CLAUDIA B. · 2017 to 2022
–
CSRD VA IK2 CX001356NIDA NIH HHS P50 DA042012
6 · The paper itself

Abstract

Diffusion tractography allows identification and measurement of structural tracts in the human brain previously associated with motivated behavior in animal models. Recent findings indicate that the structural properties of a tract connecting the midbrain to nucleus accumbens (NAcc) are associated with a diagnosis of stimulant use disorder (SUD), but not relapse. In this preregistered study, we used diffusion tractography in a sample of patients treated for SUD (

Indexed as

Central Nervous System StimulantsNucleus AccumbensPrefrontal CortexSubstance-Related DisordersWhite MatterAnimalsHumansRecurrenceCentral Nervous System Stimulantsaccumbensaddictiondiffusioninsularelapse

Identifiers

PMID35727973
PMCPMC9245633
OpenAlexW4283205284

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.