Evidence map›Paper›PMID 35727444›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2022

SpeedyGenesXL: an Automated, High-Throughput Platform for the Preparation of Bespoke Ultralarge Variant Libraries for Directed Evolution.

Joanna C Sadler, Neil Swainston, Mark S Dunstan, Andrew Currin, Douglas B Kell

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 83% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Joanna C SadlerSchool of Chemistry, The University of Manchester, Manchester, UK.
Neil SwainstonManchester Institute of Biotechnology, University of Manchester, Manchester, UK.
Mark S DunstanSchool of Chemistry, The University of Manchester, Manchester, UK.
Andrew CurrinManchester Institute of Biotechnology, University of Manchester, Manchester, UK.
Douglas B KellDepartment of Biochemistry and Systems Biology, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK. dbk@liv.ac.uk.
University of Manchester · GBNovo Nordisk Foundation · DKSynlab Czech (Czechia) · CZ

Funding

Biotechnology and Biological Sciences Research Council BB/M017702/1Biotechnology and Biological Sciences Research Council BB/P009042/1Biotechnology and Biological Sciences Research Council BB/R000093/1
6 · The paper itself

Abstract

Directed evolution of proteins is a highly effective strategy for tailoring biocatalysts to a particular application, and is capable of engineering improvements such as k

Indexed as

Directed Molecular EvolutionProteinsGene LibraryProteinsAutomationBespoke gene variant library synthesisDirected evolutionSynthetic biology

Identifiers

PMID35727444
OpenAlexW4285218443

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.