Observational studyTechniques in coloproctology2022
MRI biomarker of muscle composition is associated with severity of pelvic organ prolapse.
Observational study in Techniques in coloproctology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 14 citations in OpenAlex.
- Prediction of late-pregnancy pelvic floor dysfunction: a nomogram model based on proton density fat fraction and synthetic magnetic resonance imaging.Quantitative imaging in medicine and surgery · 2026Article
- Recurrence After Rectopexy: Insights From Magnetic Resonance Defecography.Diseases of the colon and rectum · 2026Article
- Pelvic Organ Prolapse Association with Iliopsoas Cross-Sectional Area and Muscle Strength in Middle-Aged and Older Women.International urogynecology journal · 2026Article
- Assessment of the Impact of Vaginal Delivery on the Levator Ani Muscle Using Intravoxel Incoherent Motion MRI.International urogynecology journal · 2026Article
- Assessment of risk factors for pelvic organ prolapse using dynamic MRI combined with clinical data.Insights into imaging · 2026Article
- The Clinical Significance of Key Pelvic Floor Ultrasound Indicators in POP Management: A Retrospective Study of Diagnostic Accuracy and Therapeutic Intervention.International journal of women's health · 2026Article
- Correlation between Plane Assessment of Prolapse Degree and Pelvic Organ Prolapse Quantification Scores after Three-Dimensional Reconstruction of Female Pelvic Organ Prolapse.Gynecologic and obstetric investigation · 2026Article
- Characterizing pelvic organ descent in women after radical cystectomy: an exploratory analysis.World journal of urology · 2025Article
- MR Defecography Improves Diagnosis of Postoperative Pelvic Floor Dysfunction After Gynecological Surgery.Diagnostics (Basel, Switzerland) · 2025Review
- Bidirectional Relationships between Sarcopenia and Pelvic Floor Disorders.International journal of environmental research and public health · 2024Review
- Diagnostic Value of Dynamic Magnetic Resonance Imaging (dMRI) of the Pelvic Floor in Genital Prolapses.Biomedicines · 2023Review
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe pathophysiology of pelvic organ prolapse is largely unknown. We hypothesized that reduced muscle mass on magnetic resonance defecography (MRD) is associated with increased pelvic floor laxity. The aim of this study was to compare the psoas and puborectalis muscle mass composition and cross-sectional area among patients with or without pelvic laxity.
methodsAn observational retrospective study was conducted on women > age 18 years old who had undergone MRD for pelvic floor complaints from January 2020 to December 2020 at Stanford Pelvic Health Center. Pelvic floor laxity, pelvic organ descent, and rectal prolapse were characterized by standard measurements on MRD and compared to the psoas (L4 level) and puborectalis muscle index (cross-sectional area adjusted by height) and relative fat fraction, quantified by utilizing a 2-point Dixon technique. Regression analysis was used to quantify the association between muscle characteristics and pelvic organ measurements.
resultsThe psoas fat fraction was significantly elevated in patients with abnormally increased resting and strain H and M lines (p < 0.05) and increased with rising grades of Oxford rectal prolapse (p = 0.0001), uterovaginal descent (p = 0.001) and bladder descent (p = 0.0005). In multivariate regression analysis, adjusted for age and body mass index, the psoas fat fraction (not muscle index) was an independent risk factor for abnormal strain H and M line; odds ratio (95% confidence interval) of 17.8 (2-155.4) and 18.5 (1.3-258.3) respectively, and rising Oxford grade of rectal prolapse 153.9 (4.4-5383) and bladder descent 12.4 (1.5-106). Puborectalis fat fraction was increased by rising grades of Oxford rectal prolapse (p = 0.0002).
conclusionsSeverity of pelvic organ prolapse appears to be associated with increasing psoas muscle fat fraction, a biomarker for reduced skeletal muscle mass. Future prospective research is needed to determine if sarcopenia may predict postsurgical outcomes after pelvic organ prolapse repair.
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