Evidence map›Paper›PMID 35727376›Full record

ArticleClinical oral investigations2022

Chronic mechanical irritation enhances the effect of tobacco and alcohol on the risk of oral squamous cell carcinoma: a case-control study in Argentina.

Eduardo David Piemonte, Jerónimo Pablo Lazos, Gerardo Marcelo Gilligan, René Luis Panico, Laura Cecilia Werner, Yi-Hsin Yang, Saman Warnakulasuriya

Abstract read
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In one paragraph

Article in Clinical oral investigations, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Advances in Photothermal Therapy for Oral Cancer.International journal of molecular sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Eduardo David PiemonteOral Medicine Department, Dentistry College, Universidad Nacional de Córdoba, Av. Haya de la Torre s/n, Ciudad Universitaria, 5000, Córdoba, Argentina. eduardo.piemonte@unc.edu.ar.ORCID http://orcid.org/0000-0001-5955-1139
Jerónimo Pablo LazosOral Medicine Department, Dentistry College, Universidad Nacional de Córdoba, Av. Haya de la Torre s/n, Ciudad Universitaria, 5000, Córdoba, Argentina.ORCID https://orcid.org/0000-0002-0881-9614
Gerardo Marcelo GilliganOral Medicine Department, Dentistry College, Universidad Nacional de Córdoba, Av. Haya de la Torre s/n, Ciudad Universitaria, 5000, Córdoba, Argentina.ORCID https://orcid.org/0000-0002-5201-1444
René Luis PanicoOral Medicine Department, Dentistry College, Universidad Nacional de Córdoba, Av. Haya de la Torre s/n, Ciudad Universitaria, 5000, Córdoba, Argentina.ORCID https://orcid.org/0000-0002-5833-5546
Laura Cecilia WernerOral Medicine Service, Hospital Alemán, Buenos Aires, Argentina.ORCID https://orcid.org/0000-0003-3601-9902
Yi-Hsin YangNational Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan.ORCID https://orcid.org/0000-0002-9581-2778
Saman WarnakulasuriyaFaculty of Dentistry, Oral & Craniofacial Sciences, King's College London & WHO Collaborating Centre for Oral Cancer, London, UK.ORCID https://orcid.org/0000-0003-2103-0746
Universidad Nacional de Córdoba · ARHospital Alemán · ARKing's College London · GBNational Health Research Institutes · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesOral squamous cell carcinoma (OSCC) is a multifactorial disease. The individual effect of each risk factor for OSCC may be conditioned by the frequency of other factors. The objective of this study was to identify the association between chronic mechanical irritation (CMI) and OSCC and to analyse the influence of CMI on other important risk factors for OSCC. MATERIALS AND

methodsA prospective and age/sex-matched case-control study was performed in two institutions from Argentina between 2009 and 2019, with consecutive and newly diagnosed OSCC. The frequencies of tobacco, alcohol, and CMI were analysed using conditional logistic regression. Cumulative tobacco consumption and the presence of CMI were analysed using the Mann-Whitney test.

resultsCMI and OSCC were associated with an OR of 7.02 (95% CI 3.57-13.78, p < 0.001). The combination of CMI and alcohol demonstrated the highest risk of OSCC (OR 53.83, CI 95% 8.04-360, p < 0.0001), followed by the combination of CMI, tobacco, and alcohol (OR 48.06, CI 95% 8.47-272, p < 0.0001). The combination of CMI and tobacco was also significant (OR 5.61, CI 95% 1.07-29.54, p = 0.042). Patients with CMI developed OSCC with less cumulative tobacco use compared with those without CMI.

conclusionCMI is an independent risk factor for OSCC, and it could act as a risk modifier among tobacco and alcohol users having an enhancing effect. CLINICAL RELEVANCE: Elimination of CMI could decrease the risk of OSCC.

Indexed as

Carcinoma, Squamous CellHead and Neck NeoplasmsMouth NeoplasmsArgentinaCase-Control StudiesHumansProspective StudiesRisk FactorsSmokingSquamous Cell Carcinoma of Head and NeckTobacco ProductsTobacco UseAlcoholCase-control studyChronic mechanical irritationOral squamous cell carcinomaRisk factorsTobacco

Identifiers

PMID35727376
OpenAlexW4283214841

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.