Evidence map›Paper›PMID 35727330›Full record

ArticleAnalytical and bioanalytical chemistry2022

Membrane inlet mass spectrometry method for food intake impact assessment on specific volatile organic compounds in exhaled breath.

Milena Jakšić, Andrea Mihajlović, Djordje Vujić, Stamatios Giannoukos, Boris Brkić

Open access · hybridAbstract read
In one paragraph

Article in Analytical and bioanalytical chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Milena JakšićBioSense Institute, University of Novi Sad, Dr Zorana Djindjića 1, 21000, Novi Sad, Serbia. milena.jaksic@biosense.rs.ORCID http://orcid.org/0000-0003-1912-1702
Andrea MihajlovićBioSense Institute, University of Novi Sad, Dr Zorana Djindjića 1, 21000, Novi Sad, Serbia.ORCID http://orcid.org/0000-0002-7096-7415
Djordje VujićBioSense Institute, University of Novi Sad, Dr Zorana Djindjića 1, 21000, Novi Sad, Serbia.ORCID http://orcid.org/0000-0002-7055-9307
Stamatios GiannoukosDepartment of Chemistry and Applied Biosciences, ETH Zurich, HCI D 317, Vladimir-Prelog-Weg 3, CH-8093, Zurich, Switzerland.ORCID http://orcid.org/0000-0003-3045-5084
Boris BrkićBioSense Institute, University of Novi Sad, Dr Zorana Djindjića 1, 21000, Novi Sad, Serbia. boris.brkic@biosense.rs.ORCID http://orcid.org/0000-0003-2427-7154
University of Novi Sad · RSETH Zurich · CH

Funding

Horizon 2020 Framework Programme 817732Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja 451-03-68/2022-14/200358
6 · The paper itself

Abstract

This research work describes the development of a novel bioanalytical method for the assessment of food impact on selected exhaled breath volatile organic compounds (VOCs) using a fast and portable screening VOC prototype sensor based on membrane inlet mass spectrometry (MIMS). Method and sensor prototype functionality was verified by obtaining good response times, linearity in the examined concentration ranges, and sensitivity and repeatability for several breath VOCs-acetone, ethanol, n-pentane, and isoprene. A new VOC sensor prototype was also proven to be sensitive enough for selected breath VOC quantification with limits of detection at low part per billion (ppb) levels-5 ppb for n-pentane, 10 ppb for acetone and ethanol, and 25 ppb for isoprene. Food impact assessment was accomplished by tracking the levels of acetone, ethanol, n-pentane, and isoprene in exhaled breath samples collected from 50 healthy participants before the meal and 60 min and 120 min after the meal. For acetone, isoprene, and n-pentane, a larger impact was noticed 120 min after the meal, while for ethanol, it was after 60 min. Obtained VOC levels were in the expected concentration ranges. Mean values at all time points were ~ 500-900 ppb for acetone and ~ 400-600 ppb for ethanol. Most of the results for n-pentane were below 5 ppb, but the mean value for those which were detected was ~ 30 ppb. Along with samples, data about participants' lifestyle were collected via a short questionnaire, which were compared against obtained VOC levels in order to reveal some significant correlations between habits of participants and their breath VOC levels. Portable MS: monitoring of food impact on the levels of selected VOCs from exhaled breath.

Indexed as

Volatile Organic CompoundsAcetoneBaysBreath TestsEatingEthanolExhalationHumansMass SpectrometryAcetoneEthanolVolatile Organic CompoundsBreathFood impactMIMSPortableVOCs

Identifiers

PMID35727330
PMCPMC9314300
OpenAlexW4283259455

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.