ArticleEuropean radiology2022
MR elastography outperforms shear wave elastography for the diagnosis of clinically significant portal hypertension.
Article in European radiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 27 citations in OpenAlex.
- Quantitative MRI to Assess Portal Pressure in Patients With Liver Disease: Validation at 3 T.NMR in biomedicine · 2026Article
- Predicting esophageal varices in cirrhosis: diagnostic utility of MR elastography and dynamic contrast-enhanced MRI.Abdominal radiology (New York) · 2026Article
- Innovations in liver disease assessment: clinical insights from spleen stiffness measurement in chronic liver diseases.Journal of translational medicine · 2026Review
- [Novel advances following the integration of Baveno VII consensus definitions for the non-invasive testing of portal hypertension].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2026Review
- Preliminary quantitative assessment of liver and spleen MR imaging and elastography in clinically significant portal hypertension.Scientific reports · 2026Article
- Splanchnic hemodynamic parameters measured with 4D flow MRI can diagnose severe portal hypertension.European radiology · 2026Article
- Development of a nomogram model based on spleen volume change to predict high-risk esophageal varices in patients with liver cirrhosis.Frontiers in surgery · 2025Article
- Standard technique in Japan for measuring hepatic venous pressure gradient.Journal of gastroenterology · 2025Review
- Feasibility and performance of spin-echo EPI MR elastography at 3 Tesla for staging hepatic fibrosis in the presence of hepatic iron overload.Abdominal radiology (New York) · 2024Article
- The impact of hepatic and splenic volumetric assessment in imaging for chronic liver disease: a narrative review.Insights into imaging · 2024Review
- Non-Invasive Diagnostic Tests for Portal Hypertension in Patients with HBV- and HCV-Related Cirrhosis: A Comprehensive Review.Medicina (Kaunas, Lithuania) · 2024Review
- Superiority of spleen stiffness on two-dimensional magnetic resonance elastography over liver stiffness and serum tests in assessing portal hypertension in chronic liver disease.Quantitative imaging in medicine and surgery · 2024Article
- Postprandial splenic stiffness changes on magnetic resonance elastography in a young healthy population.NMR in biomedicine · 2024Article
- Recent Advances in the Pathogenesis and Clinical Evaluation of Portal Hypertension in Chronic Liver Disease.Gut and liver · 2024Review
- Spleen stiffness measurement as a non-invasive assessment in patients with portal hypertension.eGastroenterology · 2024Review
- MR Elastography: Practical Questions, From theAJR. American journal of roentgenology · 2024Review
- Magnetic resonance elastography for noninvasive detection of liver fibrosis: is there an added value of 3D acquisition?Abdominal radiology (New York) · 2023Article
- Abdominal MR elastography with multiple driver arrays: performance and repeatability.Abdominal radiology (New York) · 2023Article
- Performance of native and gadoxetate-enhanced liver and spleen TAbdominal radiology (New York) · 2022Article
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Authors and funding
16 authors at 5 institutions in 4 countries.
Funding
Abstract
objectivesPortal hypertension (PH) is associated with complications such as ascites and esophageal varices and is typically diagnosed through invasive hepatic venous pressure gradient (HVPG) measurement, which is not widely available. In this study, we aim to assess the diagnostic performance of 2D/3D MR elastography (MRE) and shear wave elastography (SWE) measures of liver and spleen stiffness (LS and SS) and spleen volume, to noninvasively diagnose clinically significant portal hypertension (CSPH) using HVPG measurement as the reference.
methodsIn this prospective study, patients with liver disease underwent 2D/3D MRE and SWE of the liver and spleen, as well as HVPG measurement. The correlation between MRE/SWE measures of LS/SS and spleen volume with HVPG was assessed. ROC analysis was used to determine the utility of MRE, SWE, and spleen volume for diagnosing CSPH.
resultsThirty-six patients (M/F 22/14, mean age 55 ± 14 years) were included. Of the evaluated parameters, 3D MRE SS had the strongest correlation with HVPG (r = 0.686, p < 0.001), followed by 2D MRE SS (r = 0.476, p = 0.004). 3D MRE SS displayed the best performance for diagnosis of CSPH (AUC = 0.911) followed by 2D MRE SS (AUC = 0.845) and 3D MRE LS (AUC = 0.804). SWE SS showed poor performance for diagnosis of CSPH (AUC = 0.583) while spleen volume was a fair predictor (AUC = 0.738). 3D MRE SS was significantly superior to SWE LS/SS (p ≤ 0.021) for the diagnosis of CSPH.
conclusionSS measured with 3D MRE outperforms SWE for the diagnosis of CSPH. SS appears to be a useful biomarker for assessing PH severity. These results need further validation. KEY POINTS: • Spleen stiffness measured with 2D and 3D MR elastography correlates significantly with hepatic venous pressure gradient measurement. • Spleen stiffness measured with 3D MR elastography demonstrates excellent performance for the diagnosis of clinically significant portal hypertension (AUC 0.911). • Spleen stiffness measured with 3D MR elastography outperforms liver and spleen stiffness measured with shear wave elastography for diagnosis of clinically significant portal hypertension.
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