Evidence map›Paper›PMID 35727150›Full record

ArticleRadiology2023

Reduction in Chest CT Severity and Improved Hospital Outcomes in SARS-CoV-2 Omicron Compared with Delta Variant Infection.

Maria T Tsakok, Robert A Watson, Shyamal J Saujani, Mark Kong, Cheng Xie, Heiko Peschl, Louise Wing, Fiona K MacLeod, Brian Shine, Nicholas P Talbot and 3 more

Open access · greenAbstract read
In one paragraph

Article in Radiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 1 pooled it
8.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 1 synthesis or guideline pooled it, 84 citations in OpenAlex.

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1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Maria T Tsakok *From the Department of Radiology, Oxford University Hospitals NHS Foundation Trust, Headley Way, Oxford OX3 9DU, United Kingdom (M.T.T., R.A.W., S.J.S., M.K., C.X., H.P., L.W., F.K.M., B.S., N.P.T., R.E.B., D.W.E., F.G.); and Weatherall Institute of Molecular Medicine (R.A.W.), Department of Oncology (R.A.W.), Department of Physiology, Anatomy and Genetics (N.P.T.), and Big Data Institute, Nuffield Department of Population Health (D.W.E.), University of Oxford, Oxford, United Kingdom.ORCID 0000-0003-4338-115X
Robert A Watson *From the Department of Radiology, Oxford University Hospitals NHS Foundation Trust, Headley Way, Oxford OX3 9DU, United Kingdom (M.T.T., R.A.W., S.J.S., M.K., C.X., H.P., L.W., F.K.M., B.S., N.P.T., R.E.B., D.W.E., F.G.); and Weatherall Institute of Molecular Medicine (R.A.W.), Department of Oncology (R.A.W.), Department of Physiology, Anatomy and Genetics (N.P.T.), and Big Data Institute, Nuffield Department of Population Health (D.W.E.), University of Oxford, Oxford, United Kingdom.
Shyamal J SaujaniFrom the Department of Radiology, Oxford University Hospitals NHS Foundation Trust, Headley Way, Oxford OX3 9DU, United Kingdom (M.T.T., R.A.W., S.J.S., M.K., C.X., H.P., L.W., F.K.M., B.S., N.P.T., R.E.B., D.W.E., F.G.); and Weatherall Institute of Molecular Medicine (R.A.W.), Department of Oncology (R.A.W.), Department of Physiology, Anatomy and Genetics (N.P.T.), and Big Data Institute, Nuffield Department of Population Health (D.W.E.), University of Oxford, Oxford, United Kingdom.
Mark KongFrom the Department of Radiology, Oxford University Hospitals NHS Foundation Trust, Headley Way, Oxford OX3 9DU, United Kingdom (M.T.T., R.A.W., S.J.S., M.K., C.X., H.P., L.W., F.K.M., B.S., N.P.T., R.E.B., D.W.E., F.G.); and Weatherall Institute of Molecular Medicine (R.A.W.), Department of Oncology (R.A.W.), Department of Physiology, Anatomy and Genetics (N.P.T.), and Big Data Institute, Nuffield Department of Population Health (D.W.E.), University of Oxford, Oxford, United Kingdom.
Cheng XieFrom the Department of Radiology, Oxford University Hospitals NHS Foundation Trust, Headley Way, Oxford OX3 9DU, United Kingdom (M.T.T., R.A.W., S.J.S., M.K., C.X., H.P., L.W., F.K.M., B.S., N.P.T., R.E.B., D.W.E., F.G.); and Weatherall Institute of Molecular Medicine (R.A.W.), Department of Oncology (R.A.W.), Department of Physiology, Anatomy and Genetics (N.P.T.), and Big Data Institute, Nuffield Department of Population Health (D.W.E.), University of Oxford, Oxford, United Kingdom.ORCID 0000-0002-5165-9900
Heiko PeschlFrom the Department of Radiology, Oxford University Hospitals NHS Foundation Trust, Headley Way, Oxford OX3 9DU, United Kingdom (M.T.T., R.A.W., S.J.S., M.K., C.X., H.P., L.W., F.K.M., B.S., N.P.T., R.E.B., D.W.E., F.G.); and Weatherall Institute of Molecular Medicine (R.A.W.), Department of Oncology (R.A.W.), Department of Physiology, Anatomy and Genetics (N.P.T.), and Big Data Institute, Nuffield Department of Population Health (D.W.E.), University of Oxford, Oxford, United Kingdom.
Louise WingFrom the Department of Radiology, Oxford University Hospitals NHS Foundation Trust, Headley Way, Oxford OX3 9DU, United Kingdom (M.T.T., R.A.W., S.J.S., M.K., C.X., H.P., L.W., F.K.M., B.S., N.P.T., R.E.B., D.W.E., F.G.); and Weatherall Institute of Molecular Medicine (R.A.W.), Department of Oncology (R.A.W.), Department of Physiology, Anatomy and Genetics (N.P.T.), and Big Data Institute, Nuffield Department of Population Health (D.W.E.), University of Oxford, Oxford, United Kingdom.ORCID 0000-0002-8032-6718
Fiona K MacLeodFrom the Department of Radiology, Oxford University Hospitals NHS Foundation Trust, Headley Way, Oxford OX3 9DU, United Kingdom (M.T.T., R.A.W., S.J.S., M.K., C.X., H.P., L.W., F.K.M., B.S., N.P.T., R.E.B., D.W.E., F.G.); and Weatherall Institute of Molecular Medicine (R.A.W.), Department of Oncology (R.A.W.), Department of Physiology, Anatomy and Genetics (N.P.T.), and Big Data Institute, Nuffield Department of Population Health (D.W.E.), University of Oxford, Oxford, United Kingdom.ORCID 0000-0002-2666-656X
Brian ShineFrom the Department of Radiology, Oxford University Hospitals NHS Foundation Trust, Headley Way, Oxford OX3 9DU, United Kingdom (M.T.T., R.A.W., S.J.S., M.K., C.X., H.P., L.W., F.K.M., B.S., N.P.T., R.E.B., D.W.E., F.G.); and Weatherall Institute of Molecular Medicine (R.A.W.), Department of Oncology (R.A.W.), Department of Physiology, Anatomy and Genetics (N.P.T.), and Big Data Institute, Nuffield Department of Population Health (D.W.E.), University of Oxford, Oxford, United Kingdom.ORCID 0000-0002-1016-8638
Nicholas P TalbotFrom the Department of Radiology, Oxford University Hospitals NHS Foundation Trust, Headley Way, Oxford OX3 9DU, United Kingdom (M.T.T., R.A.W., S.J.S., M.K., C.X., H.P., L.W., F.K.M., B.S., N.P.T., R.E.B., D.W.E., F.G.); and Weatherall Institute of Molecular Medicine (R.A.W.), Department of Oncology (R.A.W.), Department of Physiology, Anatomy and Genetics (N.P.T.), and Big Data Institute, Nuffield Department of Population Health (D.W.E.), University of Oxford, Oxford, United Kingdom.
Rachel E BenamoreFrom the Department of Radiology, Oxford University Hospitals NHS Foundation Trust, Headley Way, Oxford OX3 9DU, United Kingdom (M.T.T., R.A.W., S.J.S., M.K., C.X., H.P., L.W., F.K.M., B.S., N.P.T., R.E.B., D.W.E., F.G.); and Weatherall Institute of Molecular Medicine (R.A.W.), Department of Oncology (R.A.W.), Department of Physiology, Anatomy and Genetics (N.P.T.), and Big Data Institute, Nuffield Department of Population Health (D.W.E.), University of Oxford, Oxford, United Kingdom.ORCID 0000-0001-7186-2677
David W Eyre *From the Department of Radiology, Oxford University Hospitals NHS Foundation Trust, Headley Way, Oxford OX3 9DU, United Kingdom (M.T.T., R.A.W., S.J.S., M.K., C.X., H.P., L.W., F.K.M., B.S., N.P.T., R.E.B., D.W.E., F.G.); and Weatherall Institute of Molecular Medicine (R.A.W.), Department of Oncology (R.A.W.), Department of Physiology, Anatomy and Genetics (N.P.T.), and Big Data Institute, Nuffield Department of Population Health (D.W.E.), University of Oxford, Oxford, United Kingdom.ORCID 0000-0001-5095-6367
Fergus Gleeson *From the Department of Radiology, Oxford University Hospitals NHS Foundation Trust, Headley Way, Oxford OX3 9DU, United Kingdom (M.T.T., R.A.W., S.J.S., M.K., C.X., H.P., L.W., F.K.M., B.S., N.P.T., R.E.B., D.W.E., F.G.); and Weatherall Institute of Molecular Medicine (R.A.W.), Department of Oncology (R.A.W.), Department of Physiology, Anatomy and Genetics (N.P.T.), and Big Data Institute, Nuffield Department of Population Health (D.W.E.), University of Oxford, Oxford, United Kingdom.
MRC Weatherall Institute of Molecular Medicine · GBUniversity of Oxford · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background The SARS-Cov-2 Omicron variant demonstrates rapid spread but reduced disease severity. Studies evaluating lung imaging findings of Omicron infection versus non-Omicron infection remain lacking. Purpose To compare the Omicron variant with the SARS-CoV-2 Delta variant according to their chest CT radiologic pattern, biochemical parameters, clinical severity, and hospital outcomes after adjusting for vaccination status. Materials and Methods This retrospective study included hospitalized adult patients with reverse transcriptase-polymerase chain reaction test results positive for SARS-CoV-2, with CT pulmonary angiography performed within 7 days of admission between December 1, 2021, and January 14, 2022. Multiple readers performed blinded radiologic analyses that included RSNA CT classification, chest CT severity score (CTSS) (range, 0 [least severe] to 25 [most severe]), and CT imaging features, including bronchial wall thickening. Results A total of 106 patients (Delta group,

Indexed as

COVID-19Hepatitis DAdultHospitalsHumansMaleMiddle AgedRetrospective StudiesSARS-CoV-2Tomography, X-Ray Computed

Identifiers

PMID35727150
PMCPMC9272784
OpenAlexW4283218898

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.