Evidence map›Paper›PMID 35727141›Full record

ArticleeLife2022

Using population selection and sequencing to characterize natural variation of starvation resistance in

Amy K Webster, Rojin Chitrakar, Maya Powell, Jingxian Chen, Kinsey Fisher, Robyn E Tanny, Lewis Stevens, Kathryn Evans, Angela Wei, Igor Antoshechkin and 2 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
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  5. Review
  6. AdvancingPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Amy K WebsterDepartment of Biology, Duke University, Durham, United States.ORCID 0000-0003-4302-8102
Rojin ChitrakarDepartment of Biology, Duke University, Durham, United States.
Maya PowellDepartment of Biology, Duke University, Durham, United States.
Jingxian ChenDepartment of Biology, Duke University, Durham, United States.
Kinsey FisherDepartment of Biology, Duke University, Durham, United States.
Robyn E TannyDepartment of Molecular Biosciences, Northwestern University, Evanston, United States.
Lewis StevensDepartment of Molecular Biosciences, Northwestern University, Evanston, United States.
Kathryn EvansDepartment of Molecular Biosciences, Northwestern University, Evanston, United States.
Angela WeiDepartment of Biology, Duke University, Durham, United States.
Igor AntoshechkinDivision of Biology, California Institute of Technology, Pasadena, United States.
Erik C AndersenDepartment of Molecular Biosciences, Northwestern University, Evanston, United States.ORCID 0000-0003-0229-9651
L Ryan BaughDepartment of Biology, Duke University, Durham, United States.ORCID 0000-0003-2148-5492
Duke University · USNorthwestern University · USCalifornia Institute of Technology · USUniversity of North Carolina at Chapel Hill · US

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Discovery of conserved molecular mechanisms underlying population-wide variation in toxin responsesR01ES029930 · NIEHS · NORTHWESTERN UNIVERSITY · PI ANDERSEN, ERIK CHRISTIAN, BAUGH, LARRY RYAN · 2019 to 2023
$3.2M
Genetics and Genomics Training GrantT32GM136627 · NIGMS · DUKE UNIVERSITY · PI ALLISON E ASHLEY-KOCH · 2020 to 2026
$3.1M
Systemic, maternal and transgenerational effects of nutrient stressR01GM117408 · NIGMS · DUKE UNIVERSITY · PI BAUGH, LARRY RYAN · 2015 to 2022
$2.5M
Genetic and Genomic Analysis of Starvation Resistance in C. elegansR01GM143159 · NIGMS · DUKE UNIVERSITY · PI BAUGH, LARRY RYAN · 2021 to 2024
$1.2M
NIEHS NIH HHS R01 ES029930NIGMS NIH HHS R01 GM117408NIGMS NIH HHS R01 GM143159NIH HHS P40 OD010440
6 · The paper itself

Abstract

Starvation resistance is important to disease and fitness, but the genetic basis of its natural variation is unknown. Uncovering the genetic basis of complex, quantitative traits such as starvation resistance is technically challenging. We developed a synthetic-population (re)sequencing approach using molecular inversion probes (MIP-seq) to measure relative fitness during and after larval starvation in

Indexed as

Caenorhabditis elegans ProteinsStarvationAnimalsCaenorhabditis elegansForkhead Transcription FactorsGenome-Wide Association StudyInsulinCaenorhabditis elegans ProteinsForkhead Transcription FactorsInsulinC. elegansdevelopmental biologydiapausegeneticsgenomicsinsulinirldL1 arrestmolecular inversion probestarvation

Identifiers

PMID35727141
PMCPMC9262388
OpenAlexW4283277021

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.