Evidence map›Paper›PMID 35726905›Full record

ReviewThe oncologist2022

Unmet Needs in Oncology Clinical Research and Treatment in Africa: Focus on Ghana.

Lewis R Roberts, Brian M Rivers, Clayton C Yates, Lisa A Newman, Benjamin D Sarkodie, Melissa B Davis, Yaw Asare-Aboagye, Alex A Adjei, Adalynn E Harris, Baffour Awuah

Open access · goldAbstract readReview
In one paragraph

Review in The oncologist, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Late-Stage Diagnosis of Breast Cancer in Ghana: Needs for Patient and Public Education.Journal of cancer education : the official journal of the American Association for Cancer Education · 2025
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Targeting CD24 as a novel immunotherapy for solid cancers.Cell communication and signaling : CCS · 2023
    Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 3 countries.

Lewis R RobertsMayo Clinic, Rochester, MN, USA.ORCID 0000-0001-7885-8574
Brian M RiversMorehouse School of Medicine, Atlanta, GA, USA.
Clayton C YatesTuskegee University, Tuskegee, AL, USA.
Lisa A NewmanWeill Cornell Medicine, New York, NY, USA.
Benjamin D SarkodieUniversity of Ghana Medical School, Accra, Ghana.
Melissa B DavisWeill Cornell Medical College and Englander Institute of Precision Medicine, New York, NY, USA.
Yaw Asare-AboagyeDrugs for Neglected Diseases Initiative, Geneva, Switzerland.
Alex A AdjeiMayo Clinic, Rochester, MN, USA.
Adalynn E HarrisQED, Brisbane, CA, USA.
Baffour AwuahMinistry of Health, Accra, Ghana.
Cornell University · USMayo Clinic in Arizona · USDrugs for Neglected Diseases Initiative · CHMinistry of Health · GHMorehouse School of Medicine · USTuskegee University · USUniversity of Ghana · GH

Funding

The DARC side of Breast Cancer Disparities - African Ancestry and Cancer- Related Immune ResponseR01CA259396 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI DAVIS, MELISSA B, YATES, CLAYTON · 2021 to 2025
$2.4M
5th Annual International Symposium: Improving Breast Cancer Management and OutcomesR13CA261076 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI DAVIS, MELISSA B · 2021 to 2021
$20k
NCI NIH HHS R01 CA259396NCI NIH HHS R13 CA261076
6 · The paper itself

Abstract

Cancer incidence is increasing worldwide and is a major cause of mortality. The relative magnitude of the increase is remarkably high in low human development index (HDI; 95%) and medium HDI (64%) countries. On the African continent, a corresponding increase in cancer burden is predicted, particularly for sub-Saharan Africa. Current epidemiologic data indicate that mortality rates of certain cancers, such as breast and cervical cancers, in sub-Saharan Africa are the highest in the world, and the cancer risks are broadly comparable to the risks in high-income countries, such as the United States and Europe. Although emerging data alludes to the unique genetic profile of cancer in African populations, most cancer therapies are introduced to Africa without confirmatory clinical trials. Therefore, there is an increasing need for clinical trials directed toward prevention, screening, diagnosis, and identification of innovative treatments in the African context. This review will discuss the increasing cancer burden in Africa, with a particular focus on Ghana, unmet clinical needs in cancer, current medical systems, clinical trial regulatory systems, and challenges to clinical trial recruitment.

Indexed as

Uterine Cervical NeoplasmsEuropeFemaleGhanaHumansIncidencecancer burdenclinical trialdisparities in cancer careGhanasub-Saharan Africa

Identifiers

PMID35726905
PMCPMC9438909
OpenAlexW4283218530

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.