Evidence map›Paper›PMID 35726854›Full record

ArticleeLife2022

Rapid adaptation of a complex trait during experimental evolution of

Tracy M Smith, Madison A Youngblom, John F Kernien, Mohamed A Mohamed, Sydney S Fry, Lindsey L Bohr, Tatum D Mortimer, Mary B O'Neill, Caitlin S Pepperell

Open access · goldAbstract read
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Article
  3. mSystems · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. Systematic in vitro evolution inScience (New York, N.Y.) · 2024
    Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Tracy M Smith *New York Genome Center, New York, United States.
Madison A Youngblom *Department of Medical Microbiology and Immunology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, United States.ORCID 0000-0003-4816-1113
John F KernienDepartment of Medical Microbiology and Immunology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, United States.
Mohamed A MohamedDepartment of Medical Microbiology and Immunology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, United States.ORCID 0000-0003-4222-5112
Sydney S FryDepartment of Medical Microbiology and Immunology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, United States.
Lindsey L BohrDepartment of Medical Microbiology and Immunology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, United States.
Tatum D MortimerDepartment of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, United States.ORCID 0000-0001-6255-690X
Mary B O'NeillLaboratoire de Biochimie (LBC), Chimie Biologie et Innovation, ESPCI Paris, PSL Université, Paris, France.
Caitlin S PepperellDepartment of Medical Microbiology and Immunology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, United States.ORCID 0000-0002-6324-1333
University of Wisconsin–Madison · USHarvard University · USNew York Genome Center · USUniversité Paris Sciences et Lettres · FR

Funding

GRADUATE TRAINING IN MOLECULAR BIOSCIENCEST32GM007215 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI HULL, CHRISTINA M · 1985 to 2018
$22.5M
PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM007133 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI PERNA, NICOLE T · 1985 to 2023
$16.5M
Drifting to victory: resolving the paradox of M.tuberculosis evolutionR01AI113287 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI Caitlin S Pepperell · 2015 to 2026
$6.5M
INTERDISCIPLINARY PROGRAM IN BACTERIAL PATHOGENESIST32AI055396 · NIAID · UNIVERSITY OF WASHINGTON · PI FANG, FERRIC C · 2003 to 2019
$2.8M
NIAID NIH HHS R01 AI113287NIAID NIH HHS T32 AI055396NIGMS NIH HHS T32 GM007133NIGMS NIH HHS T32 GM007215
6 · The paper itself

Abstract

Tuberculosis (TB), caused by

Indexed as

Mycobacterium tuberculosisTuberculosisBiofilmsHumansMultifactorial Inheritancebiofilmsexperimental evolutiongeneticsgenomicsinfectious diseasemicrobiologyMycobacterium tuberculosispopulation genetics

Identifiers

PMID35726854
PMCPMC9213004
OpenAlexW4283214442

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.