Evidence map›Paper›PMID 35726847›Full record

ArticleCell transplantation

Exosomes Derived From Mesenchymal Stem Cells Pretreated With Ischemic Rat Heart Extracts Promote Angiogenesis via the Delivery of DMBT1.

Yi Xiao, Ye Zhang, Yuzhang Li, Nanyin Peng, Qin Liu, Danyang Qiu, Justin Cho, Cesario V Borlongan, Guolong Yu

RetractedOpen access · goldAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell transplantation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

  1. Exosome: an overview on enhanced biogenesis by small molecules.Naunyn-Schmiedeberg's archives of pharmacology · 2025
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  6. Engineering of Cell Derived-Nanovesicle as an Alternative to Exosome Therapy.Tissue engineering and regenerative medicine · 2024
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Yi XiaoDivision of Cardiovascular, Xiangya Hospital, Central South University, Changsha, China.
Ye ZhangDivision of Cardiovascular, Xiangya Hospital, Central South University, Changsha, China.
Yuzhang LiDivision of Cardiovascular, Xiangya Hospital, Central South University, Changsha, China.
Nanyin PengDivision of Cardiovascular, Xiangya Hospital, Central South University, Changsha, China.
Qin LiuDivision of Cardiovascular, Xiangya Hospital, Central South University, Changsha, China.
Danyang QiuDivision of Cardiovascular, Xiangya Hospital, Central South University, Changsha, China.
Justin ChoCenter of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL, USA.
Cesario V BorlonganCenter of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL, USA.ORCID 0000-0002-2966-9782
Guolong YuDivision of Cardiovascular, Xiangya Hospital, Central South University, Changsha, China.
Xiangya Hospital Central South University · CNCentral South University · CNUniversity of South Florida · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mesenchymal stem cell-derived exosomes (MSC-Exos) have been shown to promote angiogenesis. Treating MSCs with ischemic rat brain extracts was sufficient to augment their benefits in stroke. However, no similar analyses of ischemic heart extracts have been performed to date. We aim to determine whether MSC-Exos derived from MSCs pretreated with ischemic rat heart extract were able to promote angiogenesis and to clarify underlying mechanisms. ELISA (enzyme-linked immunosorbent assay) of heart extracts revealed a significant increase of vascular endothelial growth factor (VEGF) at 24 h post-MI (myocardial infarction) modeling, and time-dependent decreases in hypoxia inducible factor-1α (HIF-1α). MTT and wound healing assays revealed human umbilical vein endothelial cells (HUVECs) migration and proliferation increased following MSC

Indexed as

ExosomesMesenchymal Stem CellsMyocardial InfarctionAnimalsHumansHuman Umbilical Vein Endothelial CellsNeovascularization, PathologicNeovascularization, PhysiologicProteomicsRatsVascular Endothelial Growth Factor AVascular Endothelial Growth Factor AangiogenesisDMBT1exosomeischemic rat heart extractsmesenchymal stem cells

Identifiers

PMID35726847
PMCPMC9218457
OpenAlexW4283276148

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.