ReviewChemistry (Weinheim an der Bergstrasse, Germany)2022
On the Evolutionary History of the Twenty Encoded Amino Acids.
Review in Chemistry (Weinheim an der Bergstrasse, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Peptide-Metal Cation Coacervate Microdroplets as Membrane-free Protocells with Enhanced Light-Induced Catalysis.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Crystal structure of epidermal growth factor domain-specificPNAS nexus · 2026Article
- Evidence that non-cognate proteinogenic amino acids generate immunogenic neoepitopes.The Journal of biological chemistry · 2026Review
- The selfish ribosome.PLoS biology · 2026Article
- Evolution of lysine and arginine biosynthesis revealed by substrate specificity of lysine biosynthetic enzymes in Thermus thermophilus.The FEBS journal · 2026Article
- Proteins Rich in Prime Mass Residues and Their Role in Cell Biology.Evolutionary bioinformatics online · 2026Article
- Prebiotic Roles of Formaldehyde as an Activating Agent and a Building Block in Solid-State Peptide Modification.ACS bio & med chem Au · 2025Article
- An Archean atmosphere rich in sulfur biomolecules.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Coenzyme-protein interactions since early life.eLife · 2025Article
- Enhanced amino acid biosynthesis in Phaffia rhodozyma via herbicide-induced selection.Journal of industrial microbiology & biotechnology · 2024Article
- Nanotechnology in Drug Delivery: Anatomy and Molecular Insight into the Self-Assembly of Peptide-Based Hydrogels.Molecules (Basel, Switzerland) · 2024Review
- An economic demand-based framework for prioritization strategies in response to transient amino acid limitations.Nature communications · 2024Article
- The Century-Long Journey of Peptide-Based Drugs.Antibiotics (Basel, Switzerland) · 2024Article
- Evolution at the Origins of Life?Life (Basel, Switzerland) · 2024Review
- Nucleophilicity of 4-(Alkylthio)-3-imidazoline Derived Enamines.Chemistry (Weinheim an der Bergstrasse, Germany) · 2024Article
- On the Evolutionary History of the Twenty Encoded Amino Acids.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022Review
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
α-Amino acids are essential molecular constituents of life, twenty of which are privileged because they are encoded by the ribosomal machinery. The question remains open as to why this number and why this 20 in particular, an almost philosophical question that cannot be conclusively resolved. They are closely related to the evolution of the genetic code and whether nucleic acids, amino acids, and peptides appeared simultaneously and were available under prebiotic conditions when the first self-sufficient complex molecular system emerged on Earth. This report focuses on prebiotic and metabolic aspects of amino acids and proteins starting with meteorites, followed by their formation, including peptides, under plausible prebiotic conditions, and the major biosynthetic pathways in the various kingdoms of life. Coenzymes play a key role in the present analysis in that amino acid metabolism is linked to glycolysis and different variants of the tricarboxylic acid cycle (TCA, rTCA, and the incomplete horseshoe version) as well as the biosynthesis of the most important coenzymes. Thus, the report opens additional perspectives and facets on the molecular evolution of primary metabolism.
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Registered trials
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