Evidence map›Paper›PMID 35726785›Full record

Observational studyAndrology2022

Hyperbaric oxygen therapy as adjuvant treatment for surgical site infections after male-to-female gender affirmation surgery: A 10-year experience.

Marco Stizzo, Celeste Manfredi, Lorenzo Spirito, Carmine Sciorio, Javier Romero Otero, Juan Ignacio Martinez Salamanca, Felice Crocetto, Paolo Verze, Ciro Imbimbo, Ferdinando Fusco and 2 more

Open access · hybridAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Andrology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Current Use of Hyperbaric Oxygen Therapy in Plastic Surgery: A Systematic Review.Plastic and reconstructive surgery. Global open · 2026
    Article
  2. Review
  3. Review
  4. Review
  5. Voice Assistants as Consultants for Male Patients with Sexual Dysfunction: A Reliable Option?International journal of environmental research and public health · 2023
    Article
  6. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 2 countries.

Marco StizzoUrology Unit, Department of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli,", Naples, Italy.
Celeste ManfrediUrology Unit, Department of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli,", Naples, Italy.
Lorenzo SpiritoUrology Unit, Department of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli,", Naples, Italy.
Carmine SciorioUrology Unit, Manzoni Hospital, Lecco, Milan, Italy.
Javier Romero OteroDepartment of Urology, Hospital Universitario 12 Octubre, Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain.
Juan Ignacio Martinez SalamancaDepartment of Urology, Puerta de Hierro-Majadahonda University Hospital, Madrid, Spain.
Felice CrocettoDepartment of General and Specialized Surgeries, Renal Transplantation, Nephrology, Care and Pain Management, University of Naples Federico II, Naples, Italy.
Paolo VerzeUrology Unit, Department of Medicine, University of Salerno, Salerno, Italy.
Ciro ImbimboDepartment of General and Specialized Surgeries, Renal Transplantation, Nephrology, Care and Pain Management, University of Naples Federico II, Naples, Italy.
Ferdinando FuscoUrology Unit, Department of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli,", Naples, Italy.
Marco De SioUrology Unit, Department of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli,", Naples, Italy.
Davide ArcanioloUrology Unit, Department of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli,", Naples, Italy.
University of Campania "Luigi Vanvitelli" · ITUniversity of Naples Federico II · ITAlessandro Manzoni Hospital · ITHospital Universitario 12 De Octubre · ESHospital Universitario Puerta de Hierro Majadahonda · ESUniversity of Salerno · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionSeveral urological conditions that share an impairment of tissue oxygenation can benefit from hyperbaric oxygen therapy; limited evidence is available of its impact on patients undergoing male-to-female gender affirmation surgery.

aimTo evaluate the efficacy and safety of hyperbaric oxygen therapy as adjuvant treatment for surgical site infections in patients undergoing male-to-female gender affirmation surgery.

methodsThis research was conducted as an observational retrospective study. Patients undergoing male-to-female gender affirmation surgery at the principal investigators' institution from January 2009 to September 2019, with a discharge diagnosis of complicated superficial or deep wound infections, were included. All patients underwent standard management of wound infection. Subjects received/not-received hyperbaric oxygen therapy at the surgeon's discretion and were assigned to the hyperbaric oxygen therapy versus non-hyperbaric oxygen therapy group accordingly. Complete wound healing rate (primary outcome), duration of antibiotic therapy, perineal drain time, bladder catheter time, and hospital stay were recorded. All adverse events that occurred during the study period were described.

resultsA total of 156 patients underwent male-to-female gender affirmation surgery in the study period. Thirty-three patients were enrolled. Fifteen subjects belonged to the hyperbaric oxygen therapy group, the other 18 to the non-hyperbaric oxygen therapy group. No statistically significant differences were found between the two groups at baseline. Penile inversion vaginoplasty and intestinal vaginoplasty were performed in nine (60%) and six (40%) patients of the hyperbaric oxygen therapy group. Only penile inversion vaginoplasty was performed in subjects of the non-hyperbaric oxygen therapy group. Complete wound healing was obtained in 15 patients (100%) of the hyperbaric oxygen therapy group and 17 patients (94.4%) of the non-hyperbaric oxygen therapy group (p = 0.35). Duration of antibiotic therapy, perineal drain time, bladder catheter time, and hospital stay were significantly lower in the hyperbaric oxygen therapy group (p < 0.05).

conclusionOur preliminary data suggest a role of hyperbaric oxygen therapy as adjuvant treatment for surgical site infection in patients undergoing male-to-female gender affirmation surgery. Randomized controlled trials properly powered are needed to confirm our findings.

Indexed as

Gender-Affirming SurgerySurgical Wound InfectionAnti-Bacterial AgentsFemaleHumansMaleOxygenRetrospective StudiesAnti-Bacterial AgentsOxygengender affirmation surgeryhyperbaric oxygen therapyinfectionmale-to-femaletransgendervaginoplasty

Identifiers

PMID35726785
PMCPMC9541545
OpenAlexW4283206898

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.