ArticleCNS neuroscience & therapeutics2022
Altered resting-state functional connectivity of the anterior cingulate cortex in rats post noise exposure.
Article in CNS neuroscience & therapeutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Noise-induced hearing loss delays auditory learning and reduces the influence of acoustic evidence on choice.bioRxiv : the preprint server for biology · 2026Article
- Structural and Functional Brain Alterations Induced by Noise Exposure: A Comprehensive Review.NeuroSci · 2026Review
- Auditory decision-making deficits after permanent noise-induced hearing loss.Scientific reports · 2025Article
- Microglial activation in the lateral amygdala promotes anxiety-like behaviors in mice with chronic moderate noise exposure.CNS neuroscience & therapeutics · 2024Article
- Auditory-limbic-cerebellum interactions and cognitive impairments in noise-induced hearing loss.CNS neuroscience & therapeutics · 2023Article
- Altered resting-state functional connectivity of the anterior cingulate cortex in rats post noise exposure.CNS neuroscience & therapeutics · 2022Article
- Protective Effects of Molecular Hydrogen on Noise-Induced Auditory and Cognitive Dysfunction.Noise & healthArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsWe aimed to find where and how noise-induced cochlear hearing loss affects the central nervous system during the early state and identify the neural substrate for aberrant patterns that mediating noise-related anxiety-/depression- like behaviors.
methodsBroad band noise with 122 dB for 2 hours was conducted to induce hearing loss. We defined 0 day (N0D) and 10 days (N10D) post noise as the acute and sub-acute period. Behavioral tests (Open field test and light/dark test) and resting-state fMRI were computed to evaluate emotional conditions and aberrant neural activity. Functional connectivity analysis using the anterior cingulate cortex as a seed was computed to reveal the spatial distribution beyond auditory network during both periods.
resultsAnxiety-/depression-like behaviors were found in rats with noise exposure. Between-group analysis revealed that N0D rats displayed widespread reductions in functional connectivity, spanning primary somatosensory cortex, medial geniculate body, inferior colliculus, cingulate cortex, cerebellar lobule comparing with N10D rats and a similar pattern was also occurred in comparison with the control group.
conclusionTaken together, an "acoustic-causing" network accounting for distress and gating of noise exposure related anxiety/depression was proposed.
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