Evidence map›Paper›PMID 35726701›Full record

ArticleCancer medicine2023

Association of tumors having Epstein-Barr virus in surrounding lymphocytes with poor prognosis.

Norikazu Yogi, Genki Usui, Keisuke Matsusaka, Masaki Fukuyo, Ryoji Fujiki, Motoaki Seki, Shigetsugu Takano, Hiroyuki Abe, Teppei Morikawa, Tetsuo Ushiku and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Norikazu YogiDepartment of General Surgery, Graduate School of Medicine, Chiba University, Japan.
Genki UsuiDepartment of Molecular Oncology, Graduate School of Medicine, Chiba University, Japan.
Keisuke MatsusakaDepartment of Molecular Oncology, Graduate School of Medicine, Chiba University, Japan.
Masaki FukuyoDepartment of Molecular Oncology, Graduate School of Medicine, Chiba University, Japan.
Ryoji FujikiDepartment of Molecular Oncology, Graduate School of Medicine, Chiba University, Japan.
Motoaki SekiDepartment of Molecular Oncology, Graduate School of Medicine, Chiba University, Japan.ORCID 0000-0003-4207-1408
Shigetsugu TakanoDepartment of General Surgery, Graduate School of Medicine, Chiba University, Japan.ORCID 0000-0002-6495-0422
Hiroyuki AbeDepartment of Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.ORCID 0000-0003-4513-1007
Teppei MorikawaDepartment of Diagnostic Pathology, NTT Medical Center Tokyo, Tokyo, Japan.
Tetsuo UshikuDepartment of Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Masayuki OhtsukaDepartment of General Surgery, Graduate School of Medicine, Chiba University, Japan.
Atsushi KanedaDepartment of Molecular Oncology, Graduate School of Medicine, Chiba University, Japan.ORCID 0000-0002-6980-5515
Chiba University · JPThe University of Tokyo · JPNTT Medical Center · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Infection with certain viruses is an important cause of cancer. The Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium recently analyzed the whole-genome sequencing (WGS) data from 2656 cases across 21 cancer types, and indicated that Epstein-Barr virus (EBV) is detected in many different cancer cases at a higher frequency than previously reported. However, whether EBV-positive cancer cases detected by WGS-based screening correspond to those detected by conventional histopathological techniques is still unclear. In this study, to elucidate the involvement of EBV in various cancers, we reanalyzed the WGS data of the PCAWG cohort combined with the analysis of clinical samples of gastric and pancreatic cancer in our cohort. Based on EBV copy number in each case, we classified tumors into three subgroups: EBV-High, EBV-Low, and EBV-Negative. The EBV-High subgroup was found to be EBV-positive in the cancer cells themselves, whereas the EBV-Low subgroup was EBV-positive in the surrounding lymphocytes. Further, the EBV-Low subgroup showed a significantly worse prognosis for both gastric cancer and across cancer types. In summary, we classified tumors based on EBV copy number and found a unique cancer subgroup, EBV-positive in the surrounding lymphocytes, which was associated with a poor prognosis.

Indexed as

Epstein-Barr Virus InfectionsStomach NeoplasmsHerpesvirus 4, HumanHumansLymphocytesPrognosisEpstein-Barr virus (EBV)gastric cancerlymphocytepancreatic cancer

Identifiers

PMID35726701
PMCPMC9883551
OpenAlexW4283219516

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.