Evidence map›Paper›PMID 35726694›Full record

ArticleeLife2022

An M protein coiled coil unfurls and exposes its hydrophobic core to capture LL-37.

Piotr Kolesinski, Kuei-Chen Wang, Yujiro Hirose, Victor Nizet, Partho Ghosh

Open access · goldAbstract read
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Piotr KolesinskiDepartment of Chemistry & Biochemistry, University of California, San Diego, La Jolla, United States.ORCID 0000-0001-6034-8445
Kuei-Chen WangDepartment of Chemistry & Biochemistry, University of California, San Diego, La Jolla, United States.
Yujiro HiroseDivision of Host-Microbe Systems and Therapeutics, Department of Pediatrics, University of California, San Diego, La Jolla, United States.ORCID 0000-0001-6338-4767
Victor NizetDivision of Host-Microbe Systems and Therapeutics, Department of Pediatrics, University of California, San Diego, La Jolla, United States.ORCID 0000-0003-3847-0422
Partho GhoshDepartment of Chemistry & Biochemistry, University of California, San Diego, La Jolla, United States.ORCID 0000-0003-0254-5218
University of California San Diego · US

Funding

A Synchrotron Radiation Structural Biology ResourcesP30GM133894 · NIGMS · STANFORD UNIVERSITY · PI Ritimukta Sarangi · 2020 to 2026
$43.3M
Cathelicidin in Skin ImmunityR37AI052453 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Richard L Gallo, Victor Nizet · 2019 to 2026
$4.6M
How group A Streptococcus M1 protein resists cathelicidinsR21AI144901 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GHOSH, PARTHO · 2019 to 2020
$433k
NIAID NIH HHS R21 AI144901NIAID NIH HHS R37 AI052453NIGMS NIH HHS P30 GM133894
6 · The paper itself

Abstract

Surface-associated, coiled-coil M proteins of

Indexed as

Membrane ProteinsStreptococcus pyogenesHumansMembrane Proteinsantimicrobial peptidecathelicidincoiled coilsinfectious diseaseLL-37microbiologymolecular biophysicsM proteinS. pyogenesStreptococcus pyogenesstructural biology

Identifiers

PMID35726694
PMCPMC9212996
OpenAlexW4283259533

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.