Nociceptive signaling through transient receptor potential vanilloid 1 is regulated by Cyclin Dependent Kinase 5-mediated phosphorylation of T407 in vivo.
Article in Molecular pain, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
2 citing papers in PubMed, 2 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
6 authors at 2 institutions in 1 country.
Andrew ChoGene Transfer Core, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.
Bradford E HallFunctional Genomics Section, National Institute of Dental and Craniofacial Research, 2511National Institutes of Health, Bethesda, MD, USA.
Advait S LimayeGene Transfer Core, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.
Sheng WangDepartment of Neural and Pain Sciences, School of Dentistry, Program in Neuroscience, Center to Advance Chronic Pain Research, 12264The University of Maryland, Baltimore, MD, USA.
Man-Kyo ChungDepartment of Neural and Pain Sciences, School of Dentistry, Program in Neuroscience, Center to Advance Chronic Pain Research, 12264The University of Maryland, Baltimore, MD, USA.ORCID 0000-0001-7637-1148
Ashok B KulkarniGene Transfer Core, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0001-9849-3250
National Institutes of Health · USUniversity of Maryland, Baltimore · US
Funding
Molecular Roles of Cdk5 in Neuronal Functions and Pain SignalingZIADE000664 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI KULKARNI, ASHOK · 2009 to 2025
$20.4M
Trigeminal nociceptors: Neural intersection of chronic pain and alveolar bone remodelingR35DE030045 · NIDCR · UNIVERSITY OF MARYLAND BALTIMORE · PI Man-Kyo Chung · 2020 to 2026
$7.1M
Functional peripheral and central vagal neural circuits of interoception inhibiting painR01DE031477 · NIDCR · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Man-Kyo Chung, Yu Shin Kim · 2022 to 2026
$3.9M
Primary afferent plasticity in chronic painR01DE027731 · NIDCR · UNIVERSITY OF MARYLAND BALTIMORE · PI CHUNG, MAN-KYO, WEI, FENG · 2018 to 2022
$2.7M
PHOSPHORYLATION OF NEURONAL CYTOSKELETON IN NEURODEGENERATIVE DISEASESZ01DE000664 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI KULKARNI, ASHOK B. · 1996 to 2008
Cyclin dependent kinase 5 (Cdk5) is a key neuronal kinase whose activity can modulate thermo-, mechano-, and chemo-nociception. Cdk5 can modulate nociceptor firing by phosphorylating pain transducing ion channels like the transient receptor potential vanilloid 1 (TRPV1), a thermoreceptor that is activated by noxious heat, acidity, and capsaicin. TRPV1 is phosphorylated by Cdk5 at threonine-407 (T407), which then inhibits Ca
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Nociceptive signaling through transient receptor potential vanilloid 1 is regulated by Cyclin Dependent Kinase 5-mediated phosphorylation of T407 in vivo. · full record | OpenQuestion