ArticleAnnals of neurology2022
Networks Underlie Temporal Onset of Dysplasia-Related Epilepsy: A MELD Study.
Article in Annals of neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 20 citations in OpenAlex.
- Characterizing Onset Limit and Surgical Outcome Factors in Type II Focal Cortical Dysplasia-Related Epilepsy.Neurology. Clinical practice · 2026Article
- Network Colocalization Correlates of Depression and Anxiety in Pediatric Focal Cortical Dysplasia-Related Epilepsy.Annals of neurology · 2026Article
- Thalamo-Lesional Connectivity Signatures of Bilateral Tonic-Clonic Seizures in Focal Cortical Dysplasia-Related Epilepsy.Annals of clinical and translational neurology · 2026Article
- Surgical outcomes for superior frontal sulcus focal cortical dysplasia-related epilepsy.Seizure · 2026Article
- Clinical, Radiologic, and Pathologic Associations of Executive Dysfunction in Children With Focal Cortical Dysplasia-Related Epilepsy.Neurology · 2025Article
- The Expanding Frontier: The Role of Artificial Intelligence in Pediatric Neuroradiology.Children (Basel, Switzerland) · 2025Review
- ILAE neuroimaging task force highlight: MRI detection of early life epilepsy caused by focal cortical dysplasia.Epileptic disorders : international epilepsy journal with videotape · 2025Article
- Detection of Epileptogenic Focal Cortical Dysplasia Using Graph Neural Networks: A MELD Study.JAMA neurology · 2025Article
- ILAE genetic literacy series: Focal cortical dysplasia.Epileptic disorders : international epilepsy journal with videotape · 2025Review
- Article
- Mapping Functional Connectivity Signatures of Pharmacoresistant Focal Cortical Dysplasia-Related Epilepsy.Annals of neurology · 2024Article
- Article
- Review: seizure-related consolidation and the network theory of epilepsy.Frontiers in network physiology · 2024Article
- Limbic network co-localization predicts pharmacoresistance in dysplasia-related epilepsy.Annals of clinical and translational neurology · 2023Article
- Focal to bilateral tonic-clonic seizures predict pharmacoresistance in focal cortical dysplasia-related epilepsy.Epilepsia · 2023Article
- Multimodal mapping of regional brain vulnerability to focal cortical dysplasia.Brain : a journal of neurology · 2023Article
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13 authors at 3 institutions in 2 countries.
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Abstract
objectiveThe purpose of this study was to evaluate if focal cortical dysplasia (FCD) co-localization to cortical functional networks is associated with the temporal distribution of epilepsy onset in FCD.
methodsInternational (20 center), retrospective cohort from the Multi-Centre Epilepsy Lesion Detection (MELD) project. Patients included if >3 years old, had 3D pre-operative T1 magnetic resonance imaging (MRI; 1.5 or 3 T) with radiologic or histopathologic FCD after surgery. Images processed using the MELD protocol, masked with 3D regions-of-interest (ROI), and co-registered to fsaverage_sym (symmetric template). FCDs were then co-localized to 1 of 7 distributed functional cortical networks. Negative binomial regression evaluated effect of FCD size, network, histology, and sulcal depth on age of epilepsy onset. From this model, predictive age of epilepsy onset was calculated for each network.
resultsThree hundred eighty-eight patients had median age seizure onset 5 years (interquartile range [IQR] = 3-11 years), median age at pre-operative scan 18 years (IQR = 11-28 years). FCDs co-localized to the following networks: limbic (90), default mode (87), somatomotor (65), front parietal control (52), ventral attention (32), dorsal attention (31), and visual (31). Larger lesions were associated with younger age of onset (p = 0.01); age of epilepsy onset was associated with dominant network (p = 0.04) but not sulcal depth or histology. Sensorimotor networks had youngest onset; the limbic network had oldest age of onset (p values <0.05).
interpretationFCD co-localization to distributed functional cortical networks is associated with age of epilepsy onset: sensory neural networks (somatomotor and visual) with earlier onset, and limbic latest onset. These variations may reflect developmental differences in synaptic/white matter maturation or network activation and may provide a biological basis for age-dependent epilepsy onset expression. ANN NEUROL 2022;92:503-511.
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