ArticleCancer management and research2022
Predictive Value of the Hemoglobin-Albumin-Lymphocyte-Platelet (HALP) Index on the Oncological Outcomes of Locally Advanced Cervical Cancer Patients.
Article in Cancer management and research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05506748 (Association Between Preoperative HALP and Immediate Postoperative Outcomes in Patients Undergoing Pancreaticoduodenectomy), which is not on this map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Association Between Preoperative HALP and Immediate Postoperative Outcomes in Patients Undergoing Pancreaticoduodenectomy
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prognostic significance of hemoglobin, albumin, lymphocyte and platelet score in solid tumors: a pooled study.Frontiers in immunology · 2024Pooled it
- Unsupervised clustering analysis unravels the role of systemic inflammatory indices in the prognosis of patients with locally advanced cervical cancer treated with chemoradiation.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2026Article
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- Article
- Plasma proteomic biomarkers for predicting chemoradiation response in locally advanced cervical cancer.BMC women's health · 2026Article
- Prognostic value of the HALP index, erythrocyte sedimentation rate, and rheumatoid factor in rheumatoid arthritis: A laboratory-based multivariate analysis.Journal of medical biochemistry · 2026Article
- HALP outperforms systemic inflammatory biomarkers for prognosis in locally advanced cervical cancer treated with concurrent chemoradiotherapy.Biomolecules & biomedicine · 2026Article
- The predictive value of Hemoglobin-Albumin-Lymphocyte-Platelet score for maximal cytoreduction surgery in advanced-stage epithelial ovarian cancer.Revista da Associacao Medica Brasileira (1992) · 2026Article
- Association between Urinary-Extracellular-Vesicle-Enriched Proteome Dynamics and Oncological Outcomes Following Concurrent Chemoradiation in Locally Advanced Cervical Cancer.Computational and structural biotechnology journal · 2026Article
- Integrating Novel and Classical Prognostic Factors in Locally Advanced Cervical Cancer: A Machine Learning-Based Predictive Model (ESTHER Study).Journal of personalized medicine · 2025Article
- Preoperative predictors of concurrent endometrial carcinoma in patients with endometrial intraepithelial neoplasia: the role of HALP score and other inflammatory markers.Journal of the Turkish German Gynecological Association · 2025Article
- The association of HALP score with low muscle mass in older adults.Frontiers in nutrition · 2025Article
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- Predictive Value of PLR, PNI, and HALP Scores in Ovarian Cancer Staging.Cancer management and research · 2025Article
- The Utility of Immuno-Nutritional Scores in Patients with Testicular Germ Cell Tumors.Diagnostics (Basel, Switzerland) · 2024Article
- Promising predictive molecular biomarkers for cervical cancer (Review).International journal of molecular medicine · 2024Review
- Significance of Pretreatment Hemoglobin-Albumin-Lymphocyte-Platelet Index for the Prediction of Suboptimal Surgery in Epithelial Ovarian Cancer.World journal of oncology · 2024Article
- Exploring the J-shaped relationship between HALP score and mortality in cancer patients: A NHANES 1999-2018 cohort study.Frontiers in oncology · 2024Article
- Associations of HALP score with serum prostate-specific antigen and mortality in middle-aged and elderly individuals without prostate cancer.Frontiers in oncology · 2024Article
- Association of the HALP Score with Dyslipidemia: A Large, Nationwide Retrospective Study.Medicina (Kaunas, Lithuania) · 2023Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: The oncological outcomes of locally advanced cervical cancer (LACC) patients after treatment are poor and heterogeneous. This study aimed to determine the role of the hemoglobin-albumin-lymphocyte-platelet (HALP) inflammatory index in predicting oncological outcomes in LACC patients. Patients and Methods: A total of 1588 LACC patients who received radiation therapy or concurrent chemoradiation were divided into training and test sets. Characteristics, survival, and a HALP cutoff determined by X-tile software were used to build predictive survival models on the training data. Validation of the model was performed on both sets. Results: Patients with a HALP score ≤22.2 tended to have lower age (p < 0.001), lower comorbidity rate (p = 0.016), lower body mass index (p < 0.001), higher stage (p < 0.001), larger tumor size (p < 0.001), and higher likelihood to receive radiation alone than concurrent chemoradiation (p < 0.001). Survival analysis demonstrated that HALP >22.2 was independently associated with better progression-free survival (PFS; hazard ratio; HR 0.55) and overall survival (OS; HR 0.43). Validation of survival prediction by receiver-operating characteristics demonstrated a significantly improved area under the curve of survival prediction in both sets (p < 0.001) after the addition of the HALP index to the model. Conclusion: A lower HALP score was an independent predictive factor for poorer oncological outcomes. The addition of the HALP index can improve the accuracy of predicting the oncological outcomes of LACC patients.
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