Evidence map›Paper›PMID 35726299›Full record

ReviewFrontiers in molecular neuroscience2022

Exploring the Role of Posttranslational Modifications in Spinal and Bulbar Muscular Atrophy.

Neha Gogia, Luhan Ni, Victor Olmos, Fatema Haidery, Kimberly Luttik, Janghoo Lim

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in molecular neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Neha GogiaDepartment of Genetics, Yale School of Medicine, Yale University, New Haven, CT, United States.
Luhan NiDepartment of Genetics, Yale School of Medicine, Yale University, New Haven, CT, United States.
Victor OlmosDepartment of Genetics, Yale School of Medicine, Yale University, New Haven, CT, United States.
Fatema HaideryYale College, Yale University, New Haven, CT, United States.
Kimberly LuttikDepartment of Neuroscience, Yale School of Medicine, Yale University, New Haven, CT, United States.
Janghoo LimDepartment of Genetics, Yale School of Medicine, Yale University, New Haven, CT, United States.
Yale University · US

Funding

GENETICS AND GENOMICS OF HUMAN DISEASET32HD007149 · NICHD · YALE UNIVERSITY · PI James P Noonan · 1985 to 2026
$8.2M
NEUROBIOLOGY OF CORTICAL SYSTEMST32NS007224 · NINDS · YALE UNIVERSITY · PI CARDIN, JESSICA A · 1985 to 2025
$4.6M
Evaluation of a novel NLK function in lysosome biogenesis and neurodegenerative diseasesR01AG074609 · NIA · YALE UNIVERSITY · PI LIM, JANGHOO · 2021 to 2025
$4.0M
Investigation of the role of ATXN1 in oligodendroglia and neurodegenerative diseasesR01AG076154 · NIA · YALE UNIVERSITY · PI Janghoo Lim · 2022 to 2026
$3.5M
Microglial regulation of Progranulin levelsR01AG066447 · NIA · YALE UNIVERSITY · PI LIM, JANGHOO · 2020 to 2024
$3.1M
Cellular and Molecular Studies of SBMA Neuromuscular DiseaseR01NS088321 · NINDS · YALE UNIVERSITY · PI LIM, JANGHOO · 2015 to 2019
$2.2M
Investigating the Pathogenesis of Cerebellar NeurodegenerationR01NS083706 · NINDS · YALE UNIVERSITY · PI LIM, JANGHOO · 2014 to 2018
$1.8M
Regulation of inhibitory interneuron developmentR21MH119803 · NIMH · YALE UNIVERSITY · PI LIM, JANGHOO · 2019 to 2020
$461k
NIA NIH HHS R01 AG066447NIA NIH HHS R01 AG074609NIA NIH HHS R01 AG076154NICHD NIH HHS T32 HD007149NIMH NIH HHS R21 MH119803NINDS NIH HHS R01 NS083706NINDS NIH HHS R01 NS088321NINDS NIH HHS T32 NS007224
6 · The paper itself

Abstract

Spinal and Bulbar Muscular Atrophy (SBMA) is an X-linked adult-onset progressive neuromuscular disease that affects the spinal and bulbar motor neurons and skeletal muscles. SBMA is caused by expansion of polymorphic CAG trinucleotide repeats in the

Indexed as

androgen receptor (AR)neurodegenerationpolyglutamine diseaseposttranslational modification (PTM)spinal and bulbar muscular atrophy (SBMA)

Identifiers

PMID35726299
PMCPMC9206542
OpenAlexW4281704206

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.