Evidence map›Paper›PMID 35726250›Full record

ArticleACS measurement science au2022

Albumin Glycation Affects the Delivery of C-Peptide to the Red Blood Cells.

Monica J Jacobs, Morgan K Geiger, Suzanne E Summers, Charles P DeLuca, Kurt R Zinn, Dana M Spence

Open access · goldAbstract read
In one paragraph

Article in ACS measurement science au, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. UPLC-MS/MS method for quantitative determination of the advanced glycation endproductsAnalytical methods : advancing methods and applications · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Monica J JacobsDepartment of Comparative Medicine and Integrative Biology, Michigan State University, 784 Wilson Road, East Lansing, Michigan 48824, United States.
Morgan K GeigerDepartment of Chemistry, Michigan State University, 578 S Shaw Lane, East Lansing, Michigan 48824, United States.
Suzanne E SummersDepartment of Biomedical Engineering, Michigan State University, 775 Woodlot Drive, East Lansing, Michigan 48824, United States.
Charles P DeLucaInstitute for Quantitative Health Sciences & Engineering, Michigan State University, 775 Woodlot Drive, East Lansing, Michigan 48824, United States.
Kurt R ZinnDepartment of Biomedical Engineering, Michigan State University, 775 Woodlot Drive, East Lansing, Michigan 48824, United States.
Dana M SpenceDepartment of Biomedical Engineering, Michigan State University, 775 Woodlot Drive, East Lansing, Michigan 48824, United States.ORCID https://orcid.org/0000-0002-4754-6671
Michigan State University · US

Funding

From single molecule to microfluidic 3D tissue platforms: novel multiscale tools to investigate hyper-stimulated immune cells in the circulationR01NS105888 · NINDS · MICHIGAN STATE UNIVERSITY · PI Lane A. Baker, ROBERT Scott MARTIN · 2018 to 2026
$4.0M
NINDS NIH HHS R01 NS105888
6 · The paper itself

Abstract

Serum albumin is a prominent plasma protein that becomes modified in hyperglycemic conditions. In a process known as glycation, these modifications can change the structure and function of proteins, which decrease ligand binding capabilities and alter the bioavailability of ligands. C-peptide is a molecule that binds to the red blood cell (RBC) and stimulates the release of adenosine triphosphate (ATP), which is known to participate in the regulation of blood flow. C-peptide binding to the RBC only occurs in the presence of albumin, and downstream signaling cascades only occur when the albumin and C-peptide complex contains Zn

Identifiers

PMID35726250
PMCPMC9204818
OpenAlexW4223651039

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.