Evidence map›Paper›PMID 35726097›Full record

ReviewCellular and molecular life sciences : CMLS2022

Historical and current perspectives on blood endothelial cell heterogeneity in the brain.

Ryota L Matsuoka, Luke D Buck, Keerti P Vajrala, Rachael E Quick, Olivia A Card

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cellular and molecular life sciences : CMLS, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
  2. Single-Cell-Resolution Fate Mapping Reveals Embryonic Venous Origins of Fenestrated Hindbrain Choroid Plexus Vasculature.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Ryota L MatsuokaDepartment of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, 44195, USA. matsuor@ccf.org.ORCID http://orcid.org/0000-0001-6214-2889
Luke D BuckDepartment of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, 44195, USA.
Keerti P VajralaDepartment of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, 44195, USA.
Rachael E QuickDepartment of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, 44195, USA.
Olivia A CardDepartment of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, 44195, USA.
Cleveland Clinic Lerner College of Medicine · USKansas City University · US

Funding

Molecular Genetic Dissection of Fenestrated Vascular Development in the Choroid PlexusR01NS117510 · NINDS · CLEVELAND CLINIC LERNER COM-CWRU · PI MATSUOKA, RYOTA · 2020 to 2024
$1.9M
NIH HHS R01 NS117510NINDS NIH HHS R01 NS117510
6 · The paper itself

Abstract

Dynamic brain activity requires timely communications between the brain parenchyma and circulating blood. Brain-blood communication is facilitated by intricate networks of brain vasculature, which display striking heterogeneity in structure and function. This vascular cell heterogeneity in the brain is fundamental to mediating diverse brain functions and has long been recognized. However, the molecular basis of this biological phenomenon has only recently begun to be elucidated. Over the past century, various animal species and in vitro systems have contributed to the accumulation of our fundamental and phylogenetic knowledge about brain vasculature, collectively advancing this research field. Historically, dye tracer and microscopic observations have provided valuable insights into the anatomical and functional properties of vasculature across the brain, and these techniques remain an important approach. Additionally, recent advances in molecular genetics and omics technologies have revealed significant molecular heterogeneity within brain endothelial and perivascular cell types. The combination of these conventional and modern approaches has enabled us to identify phenotypic differences between healthy and abnormal conditions at the single-cell level. Accordingly, our understanding of brain vascular cell states during physiological, pathological, and aging processes has rapidly expanded. In this review, we summarize major historical advances and current knowledge on blood endothelial cell heterogeneity in the brain, and discuss important unsolved questions in the field.

Indexed as

BrainEndothelial CellsAnimalsBlood-Brain BarrierPhylogenyAngiogenesisBlood–brain barrierBrain vascularizationCell diversityFenestrationsNeurological diseasesVascular therapy

Identifiers

PMID35726097
PMCPMC9209386
OpenAlexW4283215143

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.