ArticleNature neuroscience2022
Kalium channelrhodopsins are natural light-gated potassium channels that mediate optogenetic inhibition.
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Article in Nature neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed, 1 pooled it
13.5field-weighted citation impact, top 1% of its field
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Who cites it
74 citing papers in PubMed, 1 synthesis or guideline pooled it, 140 citations in OpenAlex.
- The Role of Photobiomodulation to Modulate Ion Channels in the Nervous System: A Systematic Review.Cellular and molecular neurobiology · 2024Pooled it
- Dual pH- and Concentration-Dependent KJACS Au · 2026Article
- Channel gating in bacteriorhodopsin-like channelrhodopsins with contrasting KBiophysical journal · 2026Article
- Experimentally informed, quantitative photocycle model of the light-gated potassium channel WiChR.Biophysical journal · 2026Article
- Zebrafish as a Model for Cardiovascular Disease Using Nanotechnology and Emerging Optogenetic Tools.Biomedicines · 2026Review
- Gene therapy for epilepsy: An emerging, promising approach for a serious neurological disorder.Journal of internal medicine · 2026Review
- Theoretical analysis of low-power optogenetic suppression of action potentials in human ventricular cardiomyocytes expressed with potassium-selective channelrhodopsins.Scientific reports · 2026Article
- Efficient and sustained optogenetic control of sensory and cardiac systems.Nature biomedical engineering · 2026Article
- Light-induced analgesia provides a drug-free optical method for pain relief via activation of TRAAK kNature communications · 2026Article
- Stabilized Ion Selectivity Corrects Activation Drift in Kalium Channelrhodopsins.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- From sympathetic storm to systemic inflammation: spatiotemporal dynamics of the brain-lung axis in neurogenic pulmonary edema.Frontiers in neuroscience · 2026Review
- Application of neurodegenerative disease treatment strategies in tinnitus: mechanisms, translation, and prospects.Frontiers in aging neuroscience · 2026Review
- Technical development of two-photon optogenetic stimulation and its potential application to brain-machine interfaces.Neurophotonics · 2026Review
- Microscale maps of bursting dynamics across human hippocampal slices from patients with epilepsy.Journal of neurophysiology · 2026Article
- Multicolor photoreactions of the red light-activated channelrhodopsin Chrimson.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Octopamine instructs head direction plasticity.bioRxiv : the preprint server for biology · 2025Article
- Roadmap for direct and indirect translation of optogenetics into discoveries and therapies for humans.Nature neuroscience · 2025Review
- Optogenetic silencing by combining a rhodopsin cyclase with an engineered cGMP-gated potassium channel.Science advances · 2025Article
- Apusomonad rhodopsins: A new family of ultraviolet to blue light-absorbing rhodopsin channels.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Computational Simulations Show Proof-of-Concept for Optogenetic Suppression of Ectopic Activity in Cardiac Stem Cell Therapy.Cardiovascular engineering and technology · 2025Article
14 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors at 5 institutions in 2 countries.
Elena G GovorunovaCenter for Membrane Biology, Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston McGovern Medical School, Houston, TX, USA.ORCID http://orcid.org/0000-0003-0522-9683
Yueyang GouDepartment of Neuroscience, Baylor College of Medicine, Houston, TX, USA.ORCID http://orcid.org/0000-0002-8444-8069
Oleg A SineshchekovCenter for Membrane Biology, Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston McGovern Medical School, Houston, TX, USA.
Hai LiCenter for Membrane Biology, Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston McGovern Medical School, Houston, TX, USA.ORCID http://orcid.org/0000-0002-3969-6709
Xiaoyu LuSystems, Synthetic, and Physical Biology Program, Rice University, Houston, TX, USA.ORCID http://orcid.org/0000-0003-2426-1427
Yumei WangCenter for Membrane Biology, Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston McGovern Medical School, Houston, TX, USA.
Leonid S BrownDepartment of Physics and Biophysics Interdepartmental Group, University of Guelph, Guelph, Ontario, Canada.ORCID http://orcid.org/0000-0002-5614-8317
François St-PierreDepartment of Neuroscience, Baylor College of Medicine, Houston, TX, USA.ORCID http://orcid.org/0000-0001-8618-4135
Mingshan XueDepartment of Neuroscience, Baylor College of Medicine, Houston, TX, USA.ORCID http://orcid.org/0000-0003-1463-8884
John L SpudichCenter for Membrane Biology, Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston McGovern Medical School, Houston, TX, USA. John.L.Spudich@uth.tmc.edu.ORCID http://orcid.org/0000-0003-4167-8590
The University of Texas Health Science Center at Houston · USBaylor College of Medicine · USRice University · USThe University of Texas Health Science Center · USUniversity of Guelph · CA
Funding
Preclinical and Clincial OutcomesP50HD103555 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI Sandesh Chakravarthy Sreenath Nagamani, David Loren Nelson · 2020 to 2026
$9.9MMolecular Engineering of Natural Light-Gated Chloride Channels for Optogenetic InhibitionU01NS118288 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI SPUDICH, JOHN LEE, ST-PIERRE, FRANCOIS · 2020 to 2023
$5.2MDesigning and deploying an expanded color palette of voltage indicators engineered for multiphoton microscopyU01NS113294 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI ST-PIERRE, FRANCOIS, TOLIAS, ANDREAS · 2019 to 2021
$3.7MStructure/Function of Channelrhodopsins and Related Retinylidene ProteinsR35GM140838 · NIGMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI SPUDICH, JOHN LEE · 2021 to 2025
$3.1MEngineering designer probes for imaging membrane potential: novel parts, architectures, and platformsR01EB027145 · NIBIB · BAYLOR COLLEGE OF MEDICINE · PI ST-PIERRE, FRANCOIS · 2019 to 2022
$2.2MNIBIB NIH HHS R01 EB027145NICHD NIH HHS P50 HD103555NIGMS NIH HHS R35 GM140838NINDS NIH HHS U01 NS113294NINDS NIH HHS U01 NS118288
Abstract
Channelrhodopsins are used widely for optical control of neurons, in which they generate photoinduced proton, sodium or chloride influx. Potassium (K
Indexed as
Potassium ChannelsPotassium Channels, Voltage-GatedAnimalsChannelrhodopsinsIon Channel GatingMiceOptogeneticsPotassiumSodiumChannelrhodopsinsPotassiumPotassium ChannelsPotassium Channels, Voltage-GatedSodium
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.