ArticleThe ISME journal2022
Honey bee symbiont buffers larvae against nutritional stress and supplements lysine.
Article in The ISME journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 52 citations in OpenAlex.
- Stability in flexibility: Shifting alliances stabilize the symbioses of marine animals over 150 million years.Science advances · 2026Article
- Brain Transcriptomic Reprogramming and Comb-Associated Microbiome Variation During the Larva-To-Pupa Transition in Apis Mellifera.Archives of insect biochemistry and physiology · 2026Article
- Host Range Breadth Correlates with Genic Diversity in Honeybee Phages.Genome biology and evolution · 2026Article
- A mother's gift: Provisioning of plastid-derived structures into eggs promotes invertebrate development and dispersal.PLoS biology · 2026Article
- Comparative analysis of the gut microbiota of the sympatric stingless bee species Melipona beecheii and Melipona yucatanica.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026Article
- Origin and Evolution of Very Large Extracellular Proteins in Fructophilic Lactic Acid Bacteria.Genome biology and evolution · 2026Article
- Hidden genetic diversity among Blochmanniella endosymbionts of closely related carpenter ant populations.Journal of evolutionary biology · 2026Article
- Article
- Spatial segregation and cross-kingdom interactions drive stingless bee hive microbiome assembly.Nature communications · 2025Article
- Friend or foe? Concentration of a commensal microbe induces distinct responses in developing honey bees exposed to field-realistic pesticide concentrations.FEMS microbiology ecology · 2025Article
- Isolation and probiotic evaluation of Apilactobacillus kunkeei and Bombella sp. from Apis mellifera anatoliaca and Bombus terrestris.International microbiology : the official journal of the Spanish Society for Microbiology · 2025Article
- Evolutionary trends inmSystems · 2025Article
- Bumble bee gut microbial community structure differs between species and commercial suppliers, but metabolic potential remains largely consistent.Applied and environmental microbiology · 2025Article
- Article
- Insect-microbe interactions and their influence on organisms and ecosystems.Ecology and evolution · 2024Review
- With a little help from my friends: the roles of microbial symbionts in insect populations and communities.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- The honeybee microbiota and its impact on health and disease.Nature reviews. Microbiology · 2024Review
- Metagenomic analysis of the honey bee queen microbiome reveals low bacterial diversity and Caudoviricetes phages.mSystems · 2024Article
- Symbiotic bacteria and fungi proliferate in diapause and may enhance overwintering survival in a solitary bee.The ISME journal · 2024Article
- Multi-Element Profile Characterization of Monofloral and Polyfloral Honey from Latvia.Foods (Basel, Switzerland) · 2023Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Honey bees have suffered dramatic losses in recent years, largely due to multiple stressors underpinned by poor nutrition [1]. Nutritional stress especially harms larvae, who mature into workers unable to meet the needs of their colony [2]. In this study, we characterize the metabolic capabilities of a honey bee larvae-associated bacterium, Bombella apis (formerly Parasaccharibacter apium), and its effects on the nutritional resilience of larvae. We found that B. apis is the only bacterium associated with larvae that can withstand the antimicrobial larval diet. Further, we found that B. apis can synthesize all essential amino acids and significantly alters the amino acid content of synthetic larval diet, largely by supplying the essential amino acid lysine. Analyses of gene gain/loss across the phylogeny suggest that four amino acid transporters were gained in recent B. apis ancestors. In addition, the transporter LysE is conserved across all sequenced strains of B. apis. Finally, we tested the impact of B. apis on developing honey bee larvae subjected to nutritional stress and found that larvae supplemented with B. apis are bolstered against mass reduction despite limited nutrition. Together, these data suggest a novel role of B. apis as a nutritional mutualist of honey bee larvae.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.