ArticleNature communications2022
Augmented ultrasonography with implanted CMOS electronic motes.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Recent advances in transducers for through-tissue ultrasonic power transfer.Progress in biomedical engineering (Bristol, England) · 2026Review
- LED-based optoacoustic tomography of mice.Journal of biomedical optics · 2025Article
- A Radiological Clip Design Using Ultrasound Identification to Improve Localization.IEEE transactions on bio-medical engineering · 2024Article
- Spiral volumetric optoacoustic tomography for imaging whole-body biodynamics in small animals.Nature protocols · 2023Review
- Head-to-tail imaging of mice with spiral volumetric optoacoustic tomography.Photoacoustics · 2023Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Modern clinical practice benefits significantly from imaging technologies and much effort is directed toward making this imaging more informative through the addition of contrast agents or reporters. Here, we report the design of a battery-less integrated circuit mote acting as an electronic reporter during medical ultrasound imaging. When implanted within the field-of-view of a brightness-mode (B-mode) ultrasound imager, this mote transmits information from its location through backscattered acoustic energy which is captured within the ultrasound image itself. We prototype and characterize the operation of such motes in vitro and in vivo. Performing with a static power consumption of less than 57 pW, the motes operate at duty cycles for receiving acoustic energy as low as 50 ppm. Motes within the same field-of-view during imaging have demonstrated signal-to-noise ratios of more than 19.1 dB at depths of up to 40 mm in lossy phantom. Physiological information acquired through such motes, which is beyond what is measurable with endogenous ultrasound backscatter and which is biogeographically located within an image, has the potential to provide an augmented ultrasonography.
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Registered trials
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