Evidence map›Paper›PMID 35725771›Full record

ReviewLeukemia2022

Tipping the balance: toward rational combination therapies to overcome venetoclax resistance in mantle cell lymphoma.

Yvonne J Thus, Eric Eldering, Arnon P Kater, Marcel Spaargaren

Open access · hybridAbstract readReview
In one paragraph

Review in Leukemia, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Yvonne J ThusDepartment of Pathology, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands.
Eric ElderingLymphoma and Myeloma Center Amsterdam (LYMMCARE), Amsterdam, The Netherlands.
Arnon P KaterLymphoma and Myeloma Center Amsterdam (LYMMCARE), Amsterdam, The Netherlands.
Marcel SpaargarenDepartment of Pathology, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands. marcel.spaargaren@amsterdamumc.nl.ORCID http://orcid.org/0000-0002-3135-5109
Amsterdam University Medical Centers · NLDutch Cancer Society · NLOncode Institute · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mantle cell lymphoma (MCL), an aggressive, but incurable B-cell lymphoma, is genetically characterized by the t(11;14) translocation, resulting in the overexpression of Cyclin D1. In addition, deregulation of the B-cell lymphoma-2 (BCL-2) family proteins BCL-2, B-cell lymphoma-extra large (BCL-X

Indexed as

Antineoplastic AgentsLymphoma, B-CellLymphoma, Mantle-CellAdultbcl-X ProteinBridged Bicyclo Compounds, HeterocyclicCell Line, TumorDrug Resistance, NeoplasmHumansMyeloid Cell Leukemia Sequence 1 ProteinProto-Oncogene Proteins c-bcl-2SulfonamidesTumor MicroenvironmentAntineoplastic Agentsbcl-X ProteinBridged Bicyclo Compounds, HeterocyclicMyeloid Cell Leukemia Sequence 1 ProteinProto-Oncogene Proteins c-bcl-2Sulfonamidesvenetoclax

Identifiers

PMID35725771
PMCPMC9418002
OpenAlexW4283160733

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.