ArticleBMJ open respiratory research2022
Childhood 'bronchitis' and respiratory outcomes in middle-age: a prospective cohort study from age 7 to 53 years.
Article in BMJ open respiratory research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 18 citations in OpenAlex.
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- Incidence, antimicrobial prescribing practice, and associated healthcare costs of paediatric otorrhoea in primary care in the UK: a longitudinal population study.The British journal of general practice : the journal of the Royal College of General Practitioners · 2025Article
- Immune mRNA Expression and Fecal Microbiome Composition Change Induced by Djulis (Medicina (Kaunas, Lithuania) · 2024Article
- Chronic Bronchitis in Children and Adults: Definitions, Pathophysiology, Prevalence, Risk Factors, and Consequences.Journal of clinical medicine · 2024Review
- Associations of early life and childhood risk factors with obstructive sleep apnoea in middle-age.Respirology (Carlton, Vic.) · 2024Article
- Time to re-set our thinking about airways disease: lessons from history, the resurgence of chronic bronchitis / PBB and modern concepts in microbiology.Frontiers in pediatrics · 2024Review
- An analysis of exogenous harmful substance exposure as risk factors for COPD and hypertension co-morbidity using PSM.Frontiers in public health · 2024Article
- Early-life respiratory infections and pre-adult asthma: could there be an interaction and differential misclassification?The European respiratory journal · 2022Article
- ERS International Congress 2020: highlights from the Epidemiology and Environment Assembly.ERJ open research · 2021Article
- ERS International Congress 2020: highlights from the Paediatric Assembly.ERJ open research · 2021Review
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Authors and funding
17 authors at 9 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChronic bronchitis in childhood is associated with a diagnosis of asthma and/or bronchiectasis a few years later, however, consequences into middle-age are unknown.
objectiveTo investigate the relationship between childhood bronchitis and respiratory-related health outcomes in middle-age.
designCohort study from age 7 to 53 years.
settingGeneral population of European descent from Tasmania, Australia.
participants3202 participants of the age 53-year follow-up (mean age 53, range 51-55) of the Tasmanian Longitudinal Health Study cohort who were born in 1961 and first investigated at age 7 were included in our analysis. STATISTICAL
methodsMultivariable linear and logistic regression. The association between parent reported childhood bronchitis up to age 7 and age 53-year lung conditions (n=3202) and lung function (n=2379) were investigated.
resultsAmong 3202 participants, 47.5% had one or more episodes of childhood bronchitis, classified according to severity based on the number of episodes and duration as: 'non-recurrent bronchitis' (28.1%); 'recurrent non-protracted bronchitis' (18.1%) and 'recurrent-protracted bronchitis' (1.3%). Age 53 prevalence of doctor-diagnosed asthma and pneumonia (p-trend <0.001) and chronic bronchitis (p-trend=0.07) increased in accordance with childhood bronchitis severities. At age 53, 'recurrent-protracted bronchitis' (the most severe subgroup in childhood) was associated with doctor-diagnosed current asthma (OR 4.54, 95% CI 2.31 to 8.91) doctor-diagnosed pneumonia (OR=2.18 (95% CI 1.00 to 4.74)) and, paradoxically, increased transfer factor for carbon monoxide (z-score +0.51 SD (0.15-0.88)), when compared with no childhood bronchitis.
conclusionIn this cohort born in 1961, one or more episodes of childhood bronchitis was a frequent occurrence. 'Recurrent-protracted bronchitis', while uncommon, was especially linked to multiple respiratory outcomes almost five decades later, including asthma, pneumonia and raised lung gas transfer. These findings provide insights into the natural history of childhood 'bronchitis' into middle-age.
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