Evidence map›Paper›PMID 35725371›Full record

ArticleBMC cardiovascular disorders2022

Association of body mass index with left ventricular diastolic dysfunction among ambulatory individuals with diabetes mellitus in rural Uganda: a cross-sectional study.

Boniface Amanee Elias Lumori, Edwin Nuwagira, Fardous Charles Abeya, Abdirahman Ali Araye, Godfrey Masette, Charles K Mondo, Samson Okello, Conrad Muzoora, Anthony Muyingo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cardiovascular disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Boniface Amanee Elias LumoriDepartment of Internal Medicine, Mbarara University of Science and Technology, P.O. Box 1410, Mbarara, Uganda. lboniface@must.ac.ug.
Edwin NuwagiraDepartment of Internal Medicine, Mbarara University of Science and Technology, P.O. Box 1410, Mbarara, Uganda.
Fardous Charles AbeyaDepartment of Internal Medicine, Mbarara University of Science and Technology, P.O. Box 1410, Mbarara, Uganda.
Abdirahman Ali ArayeDepartment of Internal Medicine, Mbarara University of Science and Technology, P.O. Box 1410, Mbarara, Uganda.
Godfrey MasetteDepartment of Microbiology and Immunology, Mbarara University of Science and Technology, Mbarara, Uganda.
Charles K MondoUganda Heart Institute, Makerere University College of Health Sciences, Kampala, Uganda.
Samson OkelloDepartment of Internal Medicine, Mbarara University of Science and Technology, P.O. Box 1410, Mbarara, Uganda.
Conrad MuzooraDepartment of Internal Medicine, Mbarara University of Science and Technology, P.O. Box 1410, Mbarara, Uganda.
Anthony MuyingoDepartment of Internal Medicine, Mbarara University of Science and Technology, P.O. Box 1410, Mbarara, Uganda.
Mbarara University of Science and Technology · UGMakerere University · UGUniversity of Virginia Health System · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLeft ventricular diastolic dysfunction (LVDD) is a recognized complication of diabetes mellitus that precedes and is a risk factor for heart failure. We aimed to determine the prevalence of LVDD and its association with body mass index in ambulatory adults with diabetes mellitus in rural Uganda.

methodsWe conducted a cross-sectional study, over 5 months, to enroll 195 ambulatory Ugandan adults living with diabetes mellitus for at least five years at Mbarara Regional Referral Hospital. We collected demographic, and clinical data and measured body mass index (BMI). Echocardiography was performed to determine LVDD by assessing the mitral inflow ventricular filling velocities (E/A and E/è ratios), tricuspid regurgitant jet peak velocity, and left atrium maximum volume index. We used logistic regression to estimate the odds ratio for the association of LVDD with BMI and evaluated the variation of associations by age and hypertension status.

resultsOf the 195 participants, 141 (72.31%) were female, the mean age was 62 [standard deviation, 11.50] years, and the median duration of diabetes diagnosis was 10 [interquartile range, 7, 15] years. Eighty-six percent (n = 168) had LVDD with the majority (n = 127, 65.1%) of participants in the grade 1 category of LVDD. In the adjusted model, the odds of LVDD for each 1 kg/m

conclusionLVDD is prevalent and positively associated with BMI among ambulatory Ugandan adults living with diabetes mellitus for at least five years. The association was higher for older overweight/obese than younger individuals with normal weight. Future studies should focus on the effect of weight loss on LVDD as a possible target for the prevention of heart failure.

Indexed as

Diabetes MellitusHeart FailureVentricular Dysfunction, LeftAdultBody Mass IndexCross-Sectional StudiesDiastoleFemaleHumansMaleMiddle AgedRisk FactorsUgandaAmbulatory individualsBody mass indexDiabetes mellitusLeft ventricular diastolic dysfunctionRural Uganda

Identifiers

PMID35725371
PMCPMC9210682
OpenAlexW4283167007

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.