Evidence map›Paper›PMID 35725291›Full record

ArticleGut2022

Kyoto international consensus report on anatomy, pathophysiology and clinical significance of the gastro-oesophageal junction.

Kentaro Sugano, Stuart Jon Spechler, Emad M El-Omar, Kenneth E L McColl, Kaiyo Takubo, Takuji Gotoda, Mitsuhiro Fujishiro, Katsunori Iijima, Haruhiro Inoue, Takashi Kawai and 25 more

Open access · bronzeAbstract readConsensus Statement
In one paragraph

Article in Gut, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
13.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 64 citations in OpenAlex.

  1. Article
  2. Review
  3. A Ruler Needs a Zero Point: Defining the Gastroesophageal Junction for Length-Based Risk Stratification in Barrett's Esophagus.Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society · 2026
    Article
  4. Review
  5. Article
  6. How to Define the Gastroesophageal Junction.Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society · 2026
    Review
  7. Article
  8. Diagnostic value of real-time dynamic gastric contrast ultrasound for hiatal hernia.Hernia : the journal of hernias and abdominal wall surgery · 2026
    Article
  9. Review
  10. High Levels ofMicroorganisms · 2026
    Article
  11. Review
  12. Article
  13. Review
  14. Quality indicator survey of clinical practice guidelines for esophagogastric junction cancer 2023.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2025
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Development of a prediction score for Barrett's esophagus in Japanese health checkup settings.Esophagus : official journal of the Japan Esophageal Society · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

35 authors at 20 institutions in 16 countries.

Kentaro SuganoDivision of Gastroenterology, Department of Medicine, Jichi Medical University, Shimotsuke, Japan sugano@jichi.ac.jp.ORCID 0000-0002-8578-2974
Stuart Jon SpechlerDivision of Gastroenterology, Center for Esophageal Diseases, Baylor University Medical Center, Dallas, Texas, USA.ORCID 0000-0001-5635-5386
Emad M El-OmarMicrobiome Research Centre, St George & Sutherland Clinical Campuses, School of Clinical Medicine, Faculty of Medicine & Health, Sydney, New South Wales, Australia.ORCID 0000-0002-0011-3924
Kenneth E L McCollDivision of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
Kaiyo TakuboResearch Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.
Takuji GotodaDivision of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan.ORCID 0000-0001-6904-6777
Mitsuhiro FujishiroDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Katsunori IijimaDepartment of Gastroenterology, Akita University Graduate School of Medicine, Akita, Japan.
Haruhiro InoueDigestive Disease Center, Showa University Koto Toyosu Hospital, Tokyo, Japan.
Takashi KawaiDepartment of Gastroenterological Endoscopy, Tokyo Medical University, Tokyo, Japan.
Yoshikazu KinoshitaHyogo-prefectural Harima-Himeji General Medical Center, Himeji, Japan.
Hiroto MiwaDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Hyogo College of Medicine, Kobe, Japan.
Ken-Ichi MukaishoEducation Center for Medicine and Nursing, Shiga University of Medical Science, Otsu, Japan.
Kazunari MurakamiDepartment of Gastroenterology, Oita University Faculty of Medicine, Yuhu, Japan.
Yasuyuki SetoDepartment of Gastrointestinal Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Hisao TajiriJikei University School of Medicine, Minato-ku, Tokyo, Japan.
Shobna BhatiaSir HN Reliance Foundation Hospital, Mumbai, India.
Myung-Gyu ChoiGastroenterology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, The Republic of Korea.
Rebecca C FitzgeraldMedical Research Council Cancer Unit, Hutchison/Medical Research Council Research Centre, University of Cambridge, Cambridge, UK.
Kwong Ming FockDepartment of Gastroenterology and Hepatology, Duke NUS School of Medicine, National University of Singapore, Singapore.
Khean-Lee GohUniversity of Malaya, Kuala Lumpur, Malaysia.
Khek Yu HoDepartment of Medicine, National University of Singapore, Singapore.ORCID 0000-0002-2932-1962
Varocha MahachaiCenter of Excellence in Digestive Diseases, Thammasat University and Science Resarch and Innovation, Bangkok, Thailand.
Maria O'DonovanDepartment of Histopathology, Cambridge University Hospital NHS Trust UK, Cambridge, UK.
Robert OdzeDepartment of Pathology, Tuft University School of Medicine, Boston, Massachusetts, USA.
Richard PeekVanderbilt University Medical Center, Nashville, Tennessee, USA.
Massimo RuggeDepartment of Medicine DIMED, Surgical Pathology and Cytopathology Unit, University of Padova, Padova, Italy.ORCID 0000-0002-0679-0563
Prateek SharmaDepartment of Gastroenterology and Hepatology, University of Kansas School of Medicine, Kansas City, Kansas, USA.
Jose D SollanoDepartment of Medicine, University of Santo Tomas, Manila, Philippines.
Michael ViethInstitute of Pathology, Klinikum Bayreuth, Friedrich-Alexander University Erlangen, Nurenberg, Germany.
Justin WuInstitute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China.
Ming-Shiang WuDepartment of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.ORCID 0000-0001-5325-3974
Duowu ZouDepartment of Gastroenterology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Michio KaminishiShowa General Hospital, Tokyo, Japan.
Peter MalfertheinerMedizinixhe Klinik und Poliklinik II, Ludwig Maximillian University Klinikum, Munich, Germany.ORCID 0000-0001-8439-9036
National University of Singapore · SGThe University of Tokyo · JPAkita University · JPBaylor University Medical Center · USBayreuth Medical Center · DECambridge University Hospitals NHS Foundation Trust · GBChinese University of Hong Kong · HKHimeji Medical Center · JPHyogo Medical University · JPJichi Medical University · JPJikei University School of Medicine · JPLMU Klinikum · DENational Taiwan University Hospital · TWNihon University · JPOita University · JPShanghai Jiao Tong University · CNShiga University of Medical Science · JPShowa General Hospital · JPShowa University · JPSir H.N. Reliance Foundation Hospital and Research Centre · IN

Funding

Role of Iron and B-Catenin Activation in Gastric CarcinogenesisP01CA116087 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Maria Blanca Piazuelo · 2009 to 2026
$27.5M
Helicobacter Pylori and Gastrointestinal BiologyR01DK058587 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI PEEK, RICHARD M. · 2001 to 2024
$7.8M
NCI NIH HHS P01 CA116087NIDDK NIH HHS R01 DK058587
6 · The paper itself

Abstract

objectiveAn international meeting was organised to develop consensus on (1) the landmarks to define the gastro-oesophageal junction (GOJ), (2) the occurrence and pathophysiological significance of the cardiac gland, (3) the definition of the gastro-oesophageal junctional zone (GOJZ) and (4) the causes of inflammation, metaplasia and neoplasia occurring in the GOJZ.

designClinical questions relevant to the afore-mentioned major issues were drafted for which expert panels formulated relevant statements and textural explanations.A Delphi method using an anonymous system was employed to develop the consensus, the level of which was predefined as ≥80% of agreement. Two rounds of voting and amendments were completed before the meeting at which clinical questions and consensus were finalised.

resultsTwenty eight clinical questions and statements were finalised after extensive amendments. Critical consensus was achieved: (1) definition for the GOJ, (2) definition of the GOJZ spanning 1 cm proximal and distal to the GOJ as defined by the end of palisade vessels was accepted based on the anatomical distribution of cardiac type gland, (3) chemical and bacterial (

conclusionsThis international consensus on the new definitions of BO, GOJ and the GOJZ will be instrumental in future studies aiming to resolve many issues on this important anatomic area and hopefully will lead to better classification and management of the diseases surrounding the GOJ.

Indexed as

Barrett EsophagusGastroesophageal RefluxEsophagogastric JunctionHumansInflammationMetaplasiaBARRETT'S CARCINOMABARRETT'S OESOPHAGUSGASTROESOPHAGEAL REFLUX DISEASEGASTRO-OESPHAGEAL JUNCTIONHELICOBACTER PYLORI

Identifiers

PMID35725291
PMCPMC9279854
OpenAlexW4283170144

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.