Evidence map›Paper›PMID 35725144›Full record

ArticleAmerican journal of preventive medicine2022

Increased Risk of Postoperative Mortality Associated With Prior COVID-19 Infection.

Connie C Shao, M Chandler McLeod, Suneetha Thogaripally, Michael J Mugavero, Lauren T Gleason, Isabel C Dos Santos Marques, Daniel I Chu, Drew J Gunnells

Open access · bronzeAbstract read
In one paragraph

Article in American journal of preventive medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Connie C ShaoDepartment of Surgery, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama.
M Chandler McLeodDepartment of Surgery, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama.
Suneetha ThogaripallyCenter for Clinical and Translational Science, The University of Alabama at Birmingham, Birmingham, Alabama.
Michael J MugaveroCenter for Clinical and Translational Science, The University of Alabama at Birmingham, Birmingham, Alabama.
Lauren T GleasonDepartment of Surgery, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama.
Isabel C Dos Santos MarquesDepartment of Surgery, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama.
Daniel I ChuDepartment of Surgery, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama.
Drew J GunnellsDepartment of Surgery, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama. Electronic address: dgunnells@uabmc.edu.
University of Alabama at Birmingham · US

Funding

Project 2: Leveraging Ongoing Home Visitation Programs to Address Obesity Disparities among Underserved, Low-Income Mothers and ChildrenU54MD000502 · NIMHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI FOUAD, MONA N., GARVEY, W TIMOTHY · 2017 to 2022
$11.8M
NIMHD NIH HHS U54 MD000502
6 · The paper itself

Abstract

introductionThe impact of COVID-19 infection on surgical patients is largely described by small-cohort studies. This study characterized the risk factors for postoperative mortality among patients with preoperative COVID-19 infection.

methodsData were abstracted from the electronic medical record for patients who tested positive for COVID-19 before surgery, excluding procedures related to extracorporeal membrane oxygenation (case, March 2020-April 2021). Mortality was compared with that for patients from the American College of Surgeons National Surgical Quality Improvement Program database (control, January 2018‒February 2020) with chi-square, t test, and multivariable regression.

resultsThere were 5,209 patients in the control cohort. Among 1,072 patients with positive COVID-19 testing before surgery, 589 had surgeries with specialties tracked by the American College of Surgeons National Surgical Quality Improvement Program (General Surgery, Gynecology, Neurosurgery, Orthopedics, Thoracic, Vascular). Patients with previous COVID-19 infection were younger (age 48 vs 59 years, p<0.001), were more likely to be Black (42% vs 28%, p<0.001), and underwent fewer elective surgeries (55% vs 83%, p<0.001). Postoperative mortality was greater among the case cohort (4.4% vs 1%, p<0.001). On multivariable logistic regression, postoperative mortality increased with age (OR=1.02), emergent surgeries (OR=2.6), and previous COVID-19 infection (OR=3.8). Among patients with previous COVID-19 infection, postoperative mortality was associated with male sex (OR=2.7), higher American Society of Anesthesiologists Physical Status Classification Score (OR=4.8), and smoking history (OR=3.7).

conclusionsAlthough data abstraction was limited by the electronic medical record, postoperative mortality is nearly 6 times higher for patients infected with COVID-19 within 2 weeks before surgery when adjusting for patient- and procedure-level factors. Among those with previous COVID-19 infection, postoperative mortality is associated with male sex, American Society of Anesthesiologists Physical Status Classification Score, and smoking history.

Indexed as

COVID-19COVID-19 TestingHumansMaleMiddle AgedPostoperative ComplicationsQuality ImprovementRetrospective StudiesRisk Factors

Identifiers

PMID35725144
PMCPMC9212625
OpenAlexW4283021862

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.