Evidence map›Paper›PMID 35724928›Full record

ArticleNeuropharmacology2022

Contextual generalization of social stress learning is modulated by orexin receptors in basolateral amygdala.

Jazmine D W Yaeger, Kevin T Krupp, Tangi R Summers, Cliff H Summers

Open access · hybridAbstract read
In one paragraph

Article in Neuropharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
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  9. Stress, associative learning, and decision-making.Neurobiology of learning and memory · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jazmine D W YaegerDepartment of Biology, University of South Dakota, Vermillion, SD, 57069, USA; Neuroscience Group, Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD, 57069, USA; Veterans Affairs Research Service, Sioux Falls VA Health Care System, Sioux Falls, SD, 57105, USA; Pediatrics and Rare Diseases Group, Sanford Research, Sioux Falls, SD, 57104, USA.
Kevin T KruppDepartment of Biology, University of South Dakota, Vermillion, SD, 57069, USA; Neuroscience Group, Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD, 57069, USA.
Tangi R SummersDepartment of Biology, University of South Dakota, Vermillion, SD, 57069, USA; Neuroscience Group, Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD, 57069, USA; Veterans Affairs Research Service, Sioux Falls VA Health Care System, Sioux Falls, SD, 57105, USA.
Cliff H SummersDepartment of Biology, University of South Dakota, Vermillion, SD, 57069, USA; Neuroscience Group, Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD, 57069, USA; Veterans Affairs Research Service, Sioux Falls VA Health Care System, Sioux Falls, SD, 57105, USA. Electronic address: cliff@usd.edu.
University of South Dakota · US

Funding

The Impact of PD-1 Inhibition on Immune-Response to ChemoradiotherapyP20GM103548 · NIGMS · SANFORD RESEARCH/USD · PI MISKIMINS, W KEITH · 2012 to 2020
$20.8M
Sex Differences in the Neurobiological Significance of Orexin Stress SignalingR15MH125306 · NIMH · UNIVERSITY OF SOUTH DAKOTA · PI SUMMERS, CLIFF H · 2021 to 2021
$427k
Amygdalar Orexin Modulation of Affective DisordersR15MH104485 · NIMH · UNIVERSITY OF SOUTH DAKOTA · PI SUMMERS, CLIFF H · 2015 to 2015
$426k
National Science Foundation DGE-1633213NIGMS NIH HHS P20 GM103548NIMH NIH HHS R15 MH104485NIMH NIH HHS R15 MH125306
6 · The paper itself

Abstract

Fear-associated memories and behavior are often expressed in contexts/environments distinctively different from those in which they are created. This generalization process contributes to psychological disorders, particularly PTSD. Stress-related neurocircuits in the basolateral amygdala (BLA) receive inputs from hypothalamic orexin (Orx) neurons, which mediate neuronal activity by targeting orexin 1 (Orx

Indexed as

Avoidance LearningBasolateral Nuclear ComplexOrexin ReceptorsSocial BehaviorAmino Acid SequenceAnimalsMiceOrexinsPeptide FragmentsTrypsinOrexin ReceptorsOrexinsPeptide FragmentsTrypsin3'-[[[3-[[2-[[2-(Dimethylamino)benzoyl]amino]ethyl]amino]phenyl]amino]sulfonyl]-4′-methoxy-N,N-dimethyl-[1,1′-biphenyl]-3-carboxamide dihydrochloride[5-(2-Fluorophenyl)-2-methyl-4-thiazolyl][2(S)-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)methyl-1-pyrrolidinyl]methanone5″-chloro-N-[(5,6-Dimethoxy-2-pyridinyl)methyl]-[2,2':5′,3″-terpyridine]-3′-carboxamideAn orexin 1 receptor [Orx(1)R] antagonistAn Orx(1)R plus Orx(2)R agonistAn Orx(2)An Orx(2) antagonistAnxietyDefeatDepressionFear conditioningFreezingHypocretinLocomotionMK-1064Orexin AOrx(A) & MK-1064PTSDPYR-PRO-LEU-PRO-ASP-CYS-CYS-ARG-GLN-LYS-THR-CYS-SER-CYS-ARG-LEU-TYR-GLU-LEU-LEU–HIS–GLY-ALA-GLY-ASN–HIS–ALA-ALA-GLY-ILE-LEU-THR-LEU-NH2ResilienceSB-674042Stress-alternatives modelSusceptibilityTargeted Orx(1)R stimulationTransferenceYNT-185

Identifiers

PMID35724928
PMCPMC9285878
OpenAlexW4283034845

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.