Evidence map›Paper›PMID 35724696›Full record

ArticleGastrointestinal endoscopy2022

Biopsy channel of the endoscope as a potential source of infectious droplets during GI endoscopy.

Mark F Coughlan, Mandeep S Sawhney, Douglas K Pleskow, Umar Khan, Andy Silva-Santisteban, Awais Ahmed, Xuejun Zhang, Maria Glyavina, Liming Chen, Paul K Upputuri and 4 more

Open access · greenAbstract read
In one paragraph

Article in Gastrointestinal endoscopy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz · 2024
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Mark F CoughlanCenter for Advanced Biomedical Imaging and Photonics, Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Mandeep S SawhneyDivision of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Douglas K PleskowDivision of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Umar KhanCenter for Advanced Biomedical Imaging and Photonics, Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Andy Silva-SantistebanDivision of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Awais AhmedDivision of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Xuejun ZhangCenter for Advanced Biomedical Imaging and Photonics, Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Maria GlyavinaCenter for Advanced Biomedical Imaging and Photonics, Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Liming ChenCenter for Advanced Biomedical Imaging and Photonics, Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Paul K UpputuriCenter for Advanced Biomedical Imaging and Photonics, Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Yuri N ZakharovCenter for Advanced Biomedical Imaging and Photonics, Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Lei ZhangCenter for Advanced Biomedical Imaging and Photonics, Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Le QiuCenter for Advanced Biomedical Imaging and Photonics, Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Lev T PerelmanCenter for Advanced Biomedical Imaging and Photonics, Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA; Biological and Biomedical Sciences Program, Harvard University, Boston, Massachusetts, USA.
Beth Israel Deaconess Medical Center · USHarvard University · US

Funding

Endoscopic Fine-Needle Polarized Scanning Spectroscopy for Pancreatic Cystic Lesions DiagnosisR01EB025173 · NIBIB · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Lev T Perelman · 2017 to 2026
$4.7M
Spectro-Holographic Instrument for Dynamic Sensing of Cancer ProgressionR01CA228029 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI PERELMAN, LEV T · 2018 to 2023
$3.4M
Isolation and Assessment of Blood-Circulating Cancer Exosomes with LSS and SERS Lab on a Chip Optical Spectroscopic InstrumentR01CA218382 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI PERELMAN, LEV T · 2018 to 2022
$3.3M
(PQ7) In Vivo Cellular Optical Imaging of Esophageal Tumors and MicroenvironmentR01CA205431 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI PERELMAN, LEV T · 2016 to 2020
$2.6M
NCI NIH HHS R01 CA205431NCI NIH HHS R01 CA218382NCI NIH HHS R01 CA228029NIBIB NIH HHS R01 EB025173
6 · The paper itself

Abstract

BACKGROUND AND

aimsDuring endoscopy, droplets with the potential to transmit infectious diseases are known to emanate from a patient's mouth and anus, but they may also be expelled from the biopsy channel of the endoscope. The main goal of our study was to quantify droplets emerging from the biopsy channel during clinical endoscopy.

methodsA novel light-scattering device was used to measure droplets emanating from the biopsy channel. An endoscopy model was created, and in vitro measurements were carried out during air insufflation, air and water suctioning, and the performance of biopsy sampling. Similar measurements were then made on patients undergoing endoscopy, with all measurements taking place over 2 days to minimize variation.

resultsDuring in vitro testing, no droplets were observed at the biopsy channel during air insufflation or air and water suctioning. In 3 of 5 cases, droplets were observed during biopsy sampling, mostly when the forceps were being removed from the endoscope. In the 22 patients undergoing routine endoscopy, no droplets were observed during air insufflation and water suctioning. Droplets were detected in 1 of 11 patients during air suctioning. In 9 of 18 patients undergoing biopsy sampling and 5 of 6 patients undergoing snare polypectomies, droplets were observed at the biopsy channel, mostly when instruments were being removed from the endoscope.

conclusionsWe found that the biopsy channel may be a source of infectious droplets, especially during the removal of instruments from the biopsy channel. When compared with droplets reported from the mouth and anus, these droplets were larger in size and therefore potentially more infectious.

Indexed as

Communicable DiseasesEndoscopesBiopsyEndoscopyEndoscopy, GastrointestinalHumansWaterWater

Identifiers

PMID35724696
PMCPMC10699089
OpenAlexW4283079093

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.