ArticleJournal of critical care2022
Increased respiratory dead space could associate with coagulation activation and poor outcomes in COVID-19 ARDS.
Article in Journal of critical care, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 12 citations in OpenAlex.
- Redefining Acute Respiratory Distress Syndrome: A New Clinical Perspective.Tuberculosis and respiratory diseases · 2026Article
- Preparing for future pandemics: Automated intensive care electronic health record data extraction to accelerate clinical insights.Journal of intensive medicine · 2025Article
- Perfusion deficits may underlie lung and kidney injury in severe COVID-19 disease: insights from a multicenter international cohort study.Journal of anesthesia, analgesia and critical care · 2024Review
- Improved oxygenation in prone positioning of mechanically ventilated patients with COVID-19 acute respiratory distress syndrome is associated with decreased pulmonary shunt fraction: a prospective multicenter study.European journal of medical research · 2023Observational
- Redefining ARDS: a paradigm shift.Critical care (London, England) · 2023Review
- Letter to the editor: "Increased respiratory dead space could associate with coagulation activation and poor outcomes in COVID-19 ARDS".Journal of critical care · 2023Article
- Letter to the editor "Cardiac function in critically ill patients with severe COVID: A prospective cross-sectional study in mechanically ventilated patients".Journal of critical care · 2023Article
- Pathophysiology and Clinical Meaning of Ventilation-Perfusion Mismatch in the Acute Respiratory Distress Syndrome.Biology · 2022Review
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo determine whether VDPhys/VT is associated with coagulation activation and outcomes. MATERIALS AND
methodsWe enrolled patients with COVID-19 pneumonia who were supported by invasive mechanical ventilation and were monitored using volumetric capnography. Measurements were performed during the first 24 h of mechanical ventilation. The primary endpoint was the likelihood of being discharge alive on day 28.
resultsSixty patients were enrolled, of which 25 (42%) had high VDPhys/VT (>57%). Patients with high vs. low VDPhys/VT had higher APACHE II (10[8-13] vs. 8[6-9] points, p = 0.002), lower static compliance of the respiratory system (35[24-46] mL/cmH
conclusionsIn critically ill COVID-19 patients, increased VDPhys/VT was associated with high D-dimer levels and a lower likelihood of being discharged alive. Dichotomic VDPhys/VT could help identify a high-risk subgroup of patients neglected by the P/F ratio.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.